Abstract
The aim of this study was to compare the effects of mepartricin on the proliferation and morphology of U285 cells with those induced by suramin and finasteride, both substances which have been investigated previously. Proliferation was evaluated by the FRAME Cytotoxicity Test, exposing the cells to increasing doses of mepartricin, between 0.1 μg/ml and 5 μg/ml, from the moment of seeding for 24 hours. The morphology was evaluated by scanning electron microscope (SEM). The FRAME Test showed a statistically significant decrease (p<0.05) in proliferation at all times of observation and at all doses in those cultures exposed to mepartricin right from seeding. Those where treatment was given 24 hours later, only showed this decrease with the highest doses. SEM highlighted the reduced capacity of the cells to proliferate, confirming data from the FRAME Test. These results therefore indicate that mepartricin has an anti-proliferation effect both in the Lag phase and the logarithmic growth phase. This behaviour differs from that of suramin and finasteride, which have less marked effect on cellular growth.
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