Detrusor Morpho-functional Correlations in Obstruction due to Benign Prostatic Hyperplasia (BPH)

Abstract

This study was aimed at checking out a possible connection between detrusor primary lesions and clinical and urodynamic data in patients with cervico-prostatic obstruction. 40 patients were evaluated, of whom 32 had symptomatic benign prostatic hyperplasia and 8 were controls. A biopsy of the right side wall of the bladder was carried out. The lesions found (muscular hypertropy, fibroelastosis, alteration of the nerve fibres) in relation to their gravity, correlated to the presumable date when symptoms started and to three data from urodynamic evaluation (significant residual p.m., degree of obstruction according to Schafer's chart, presence of detrusor-motor instability). The interference of physiological ageing on results is not underestimated, but this correlation exists. However, the lack of fine quantitative evaluations of follow-up on the possible reversibility of the same lesions after removal of the obstruction, make it impossible at this stage to state how close the correlation is.