Abstract
Aim of this study is the evaluation of the increased overall inhibitory power of whole urine induced by the in-vitro addition of glycosaminoglycans (GAGs). The inhibitory power, and its variations are assessed with the Sarig test, using ionometric measurements to follow the oxalate precipitation in different experimental conditions. The study is performed on the urine collected from 160 patients with a history of calcium-oxalate lithiasis; mesoglycan, sulodexide and sodium citrate (for comparison) are each tested on 110 urine specimens. A statistical significant difference is found between the basic evaluation and after addition of GAGs, comparable with the results obtained with sodium citrate. No significant differences in activity among the three drugs are found in those cases where simultaneous testing is possible.
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