Forty patients with erectile impotence due to veno-occlusive dysfunction were treated with intracavernous injection of a four-drug mixture composed of: papaverine 12 mg/ml, prostaglandin E1 10 microg/ml, phentolamine 1 mg/ml and atropine 0.15 mg/ml. This vasoactive mixture guaranteed a rigid erection lasting at least 30 minutes in all cases. At the six-month follow-up, three patients discontinued the treatment due to personal reasons while the others are still on treatment and completely satisfied. Multi-drug intracavernous vasoactive injection is an effective therapy for veno-occlusive dysfunction of the cavernous bodies.
