Evaluation of the relationship between testosterone level in patients with urethral stricture and its effect on outcome of surgery

Abstract

Purpose:

Assessing the association between Testosterone (T)-level in patients with urethral stricture (US) and its effect on surgery outcome.

Methods:

This prospective study includes 70 cases of developing US disease and anastomotic Urethroplasty. All patients underwent retrograde and voiding urethrography, pelvi-abdominal ultrasound, and T (free and total) measurements.

Results:

A significant negative association was found between free T, age, and post-void residual volume (PVR) pre. Also, a positive association between free T and Hemoglobin (Hb) levels. Besides, an association between wound infection and total T. There was a significant lower in PVR and higher in Q-max post-urethroplasty than pre-urethroplasty. International prostate symptom score (IPSS) showed a significant decrease in post-urethroplasty and at 3 months follow up than pre-urethroplasty (p < 0.05). Diabetes mellitus, free, and total T showed significant differences between the studied groups. Also, it can predict failure results respectively at cut-off ⩽123.75 and ⩽765.8 with 85.70% sensitivity, 98.40%, and 88.90% specificity.

Conclusions:

Diabetic status, wound infection, and free and total T significantly affect the success rate in patients with the US, while preoperative PVR, Q-max, and IPSS did not affect the success rate.