Association between thyroid disorders and the Risk of developing prostate cancer: A systematic review and meta-analysis

Abstract

Objective:

To determine the association between thyroid disorders and the Risk of developing prostate cancer.

Methods:

We conducted this review following the recommendations of the Cochrane Collaboration and the PRISMA Statement. From the moment to the present, we have conducted a search strategy using MEDLINE, WEB OF SCIENCE, and GOOGLE SCHOLAR. We included cohort and case-control studies that examined the relationship between thyroid disorders and the Risk of developing prostate cancer. We assessed the Risk of bias using the Newcastle Ottawa Quality Assessment scale. Meta-analysis was conducted in Review Manager 5.4.1 (Revman^®).

Results:

We included nine studies in the analysis. The studies included were classified into two groups: those that studied hypothyroidism and those that studied hyperthyroidism. The results showed no association between thyroid abnormalities and prostate cancer risk, with an HR of 1.05 (95% CI: 0.90–1.22). Hyperthyroidism also showed no association with an HR 1.64 (95% CI: 1.00–2.69), characterized by increased serum T4 and decreased TSH. There was also no significant association with hypothyroidism, with an HR of 0.85 (95% CI: 0.67–1.10).

Conclusion:

Thyroid disorders were not associated with the Risk of developing prostate cancer.