Saline-induced Dilutional Acidosis in a Maintenance Hemodialysis Patient

Abstract

A patient with end-stage renal disease developed severe hyperchloremic acidosis (venous serum total CO₂ level of 10 mmol/L) after treatment with 16 L of isotonic saline. Analysis of this case and published literature indicates that dilutional acidosis may result when very large volumes of isotonic saline are administered intravenously, especially in patients with impaired or absent renal function.