Sage Journals: Discover world-class research

Abstract

We describe an opto-electronic device capable of measuring the hemoglobin concentration (Hgb) non-invasively and continuously, hence the percentage changes in blood volume (BV) during dialysis treatment by means of the optical absorption of monochromatic light by the blood in the arterial line. This method has been validated during several in vitro and in vivo tests, during which the system has shown a low sensitivity to all the common intra-dialytic interference factors, such as oxygen saturation (max. err.=1.6%), blood flow (max. err. =1.8%), osmotic pressure (max. err.=0.7°) and hydraulic pressure (max. err.=0.6°), a high precision (std. err.≤0.1 g/dl) and a good accordance (Hgb mean err.=0.1 g/dl; std. err.=0.38 g/dl; BV mean err.=0.1%; std. err.=1.6%) with the corresponding values derived from standard laboratory tests.

Keywords

Blood volume Hypovolemia Hemodynamics Hypotension

Get full access to this article

View all access options for this article.

References

Mancini

, Spongano

Role of hypovolemia in dialysis-induced hypotension. Blood purification in perspective: new insights and future trends.

ICAOT Press 1992; 2: 68–73.

Wilkinsons

J.S.

, Fleming

S.J.

Continuous measurement of blood hydration during ultrafiltration using optical methods.

Med Biol Eng Comp 1987; 25: 317–23.

Steuer

R.R.

, Harris

D.H.

A new optical technique for monitoring hematocrit and circulating blood volume. Its application in renal dialysis.

Dialysis Transplant 1993; 22(5): 260–5.

Maeda

, Shinzato

Newly developed circulating blood volume-monitoring system and its clinical application for measuring changes in blood volume during Hemofiltration.

Artif Organs 1986; 10(6): 452–9.

Schneditz

, Pogglitsch

A blood protein monitor for the continuous measurement of blood volume changes during hemodialysis.

Kidney Int 1990; 38: 343–6.

Mancini

, Santoro

Continuous on-line optical absorbance recording of blood volume changes during hemodialysis.

Int J Artif Organs 1993; 17(8): 691–4.

Mook

G.A.

, Van Assendelft

D.W.

Wavelength dependency of the spectrophotometric determination of blood oxygen saturation.

Clin Chim Acta 1969; 226: 170–3.

Anderson

N.M.

, Sekely

. Light-absorbing and scattering properties of non-haemolysed blood. Phys Med Biol 1967; 2: 173–84.

Janssen

F.J.

. A study of the absorption and scattering factors of light in whole blood. Med Biol Eng 1972; 10: 231–40.

10.

Twersky

. Multiple scattering of waves and optical phenomena. Journ Opt Soc Am 1962; 2: 145–71.

11.

Greenwood

R.N.

, Aldridge

Serial blood water estimations and in-line blood viscometry: the continuous measurement of blood volume during dialysis procedures.

Clin Science 1984; 66: 575–83.

12.

Fleming

S.J.

, Wilkinson

J.S.

Dialysis-induced change in erythrocyte volume. Effect on change in blood volume calculated from packed cell volume.

Clin Nephrol 1988; 29(2): 63–68.

13.

Kirschbaum

. Comparison of indirect methods to estimate plasma volume changes during hemodialysis. Int J Artif Organs 1989; 12(5): 307–13.

14.

Schallenberg

, Stiller

A new method of continuous haemoglobinometric measurement of blood volume during dialysis.

Life Supp Syst 1987; 5: 293305.

Hemoscan™: A Dialysis Machine-Integrated Blood Volume Monitor

Abstract

Keywords

Get full access to this article

References