Umbilical cord blood has been recently used as a source of hematopoietic progenitor cells for transplantation of pediatric patients. This study was performed to evaluate the feasibility of a cord blood bank for unrelated transplant. When the umbilical cord was clamped within 20 seconds after delivery, it was possible to collect 86±25 ml of cord recipients with more than 2000 CFU-GM/kg; 53% of cord blood samples were found to contain enough CFU-GM for engraftment in 50-70 kg adult patients.
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HowsJ.M., BradleyB.A., MarshJ.C.W.Growth of human umbilical-cord blood in longterm haemopoietic cultures.Lancet1992; 340: 73–6.
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BertoliniF., CorsiniC., LauriE., GoriniF., SirchiaG.Cord blood banking: evaluation of the collection procedure and of CFU-GM content.J Hematother (in press).