Artificial Pancreas,Glucose Sensors and the Impact upon Diabetology

Pfeiffer EF , Thum Ch , Clemens AH . The artificial beta-cell. A continuous control of blood sugar by external regulation of insulin infusion (glucose-controlled-insulin-infusion-system). Horm Metab Res 1974; 6: 339–42.

Pfeiffer EF , Thum Ch , Clemens AH . Die künstliche β-Zelle. Naturwissenschaften 1974; 61: 455–6.

Albisser AM , Leibel BS , Ewart TG , Davidovac Z , Both CK , Zingg W. An artificial endocrine pancreas. Diabetes 1974; 23: 289–96.

Pfeiffer EF , Kerner W. Das künstliche Pankreas: Entwicklung und Bedeutung für die Erforschung und Behandlung der Zuckerkrankheit. Verh Dtsch Ges Inn Med 1981; 87: 1408–28.

Kerner W , Thum Ch , Tamas G Jr , Beischer W , Clemens AH , Pfeiffer EF . Attempts at perfect normalization of glucose tolerance test of severe diabetics by artificial beta cell. Horm Metab Res 1976; 8 (Suppl): 256–61.

Kerner W , Navascues I , Torres AA , Pfeiffer EF . Studies on the pathogenesis of the dawn phenomenon in insulin dependent diabetics. Metabolism 1984; 33: 458–64.

Matthiessen ER , Rubin P , Christiansen JS , Svendson PA , Lauritzen T , Decken T. Diurnal pattern of insulin requirements in insulin-dependent diabetics. Scand J Clin Lab Invest 1982; 42: 63–8.

Kerner W , Pfeiffer EF . The artificial pancreas. In: Ellis Samols , ed. The endocrine pancreas. New York: Raven Press Ltd., 1991; 441–56.

Arias P , Kerner W , Zier H , Navascues I , Pfeiffer EF . Incidence of hypoglycemic episodes in diabetic patients under continuous subcutaneous insulin infusion and means of semiambulatory 24-hour continuous blood glucose monitoring. Diabetes Care 1985; 8: 134–40.

Kerner W , Beischer W , Maier V , Pfeiffer EF . Influence of insulin infusion kinetics of an artificial beta cell on blood glucose control in insulin dependent diabetics. Horm Metab Res 1979; 8 (Suppl): 71–80.

Crofford OB . DCCT update. 74th Annual Meeting, The Endocrine Society 1992.

Zier H , Kerner W , Steinbach G , Pfeiffer EF . Mobile und transportable Blutglucosemonitoren: Methodische und technische Aspekte. Verh Dtsch Ges Inn Medizin 1987; 93: 312–15.

Brückel J , Zier H , Kerner W , Pfeiffer EF . Progress in practical endocrinology: The Glucosensor Unitec Ulm - a portable monitor for continuous blood glucose measurement. Horm Metab Res 1990; 22: 382–4.

Pfeiffer EF . Continuous glucose monitoring by potable glucose sensors unmasks hyperglycemic excursions not reflected by elevated HbA1 and fructosamine values - the missing link in the DCCT (Diabetes Control and Complication Trial)? Paper given to the Diabetes-Symposium “Advanced glycosylation end-products in diabetic micro and macrovasculopathy”, Boston. 1992; 8–11.

Eller. Diss. Ulm 1993 (in press).

Kerner W , Zier H , Steinback G , A potentially implantable enzyme electrode for amperometric measurement of glucose. Horm Metab Res 1988; 20: 8–13.

Brückel J , Kerner W , Zier H , Steinbach G , Pfeiffer EF . In vivo measurement of subcutaneous glucose concentrations with an enzymatic glucose sensor and a wick method. Klin Wochenschr 1989; 67: 491–5.

Fischer U. Fundamentals of glucose sensors. Diabetic Medicine 1991: 8: 309–21.

Dolderer M , De la Fuente A , Kerner W , Zier H , Steinbach G , Pfeiffer EF . Mobile und transportable Blutglukosemonitoren: Bedeutung für Diagnose und Therapie des Diabetes mellitus. Verh Dtsch Ges Inn Med 1987; 93: 312–5.

Kerner W , Keck FS , Zier H , Pfeiffer EF . Hydrogen peroxide detecting enzyme glucose sensors are impaired by human material; paper presented to the 1. Nizza: Conference on Biomedical Engineering, 1991; 2: 17–20.

Bito L , Davson H , Levin E , Murray M , Snider N. The concentrations of free amino acids and other electrolytes in plasma in the dog. J Neurochem 1966; 13: 1057–67.

Delgado JMR , DeFeudis FV , Roth RH , Ryugo DK , Mitruka BK . Dialytrode for long term intracerebral perfusion in awake monkeys. Arch Int Pharmacodyn 1972; 198: 9–21.

Ungerstedt U , Herrera-Marchintz M , Jungnelius U , Stahle L , Tossman U , Zetterstrom T. Dopamine synaptic recordings and brain dialysis. In: Kotsiaka M , ed. Advances in dopamine research. New York: Pergamon Press, 1982; 219–31.

Tellez S , Forges NF , Roussin A. Coupling of microdialysis with capillary electrophoresis: a new approach to the study of drug transfer between two compartments of the body in freely moving rats. J Chromatogr 1992; 581: 257–66.

Jansson PA , Fowelin J , Smith U , Lönnroth P. Characterization by microdialysis of subcutaneous glucose level in subcutaneous tissue in humans. Am J Physiol 1988; 225: E128–20.

Bolinder J , Hagström E , Ungerstedt U , Arner P. Microdialysis of subcutaneous adipose tissue in vivo for continuous glucose monitoring in man. Scand J Clin Lab Invest 1989; 49: 465–74.

Keck FS , Kerner W , Meyerhoff C , Zier H , Pfeiffer EF . Combination of microdialysis and glucosensor permits continuous (on line) s.c. glucose monotoring in a patient operated device: I - In vitro evaluation. Horm Metab Res 1991; 23: 617–8.

Keck FS , Meyerhoff C , Kerner W , Siegmund T , Zier H , Pfeiffer EF . Combination of microdialysis and glucosensor permits continuous (on line) s.c. glucose monitoring in a patient operated device: II - Evaluation in animals. Horm Metab Res 1992; 24: 492–3.

Sternberg F , Meyerhoff C , Mennel FJ , Zier H , Bischof F , Pfeiffer EF . Independent method to estimate the glucose concentration in the subcutaneous tissue. Recovery in vivo. Horm Metab Res 1993; 25: 68 (A).

Meyerhoff C , Bischof F , Sternberg F , Zier H , Pfeiffer EF . On line continous monitoring of subcutaneous tissue glucose in men by combining portable glucosensor with microdialysis. Diabetologia 1993; 35: 1087–92.

Pfeiffer EF , Meyerhoff C , Bischof F , Keck FS , Kerner W. On line continous monitoring of subcutaneous tissue glucose is feasible by combining portable glucosensor with microdialysis. Horm Metab Res 1993; 25: 121–4.