The Acetate versus Bicarbonate Dialysis Controversy

Mion C.M. , Hegstrom R.M. , Boen S.T. , Scribner B.H. Substitution of sodium acetate for sodium bicarbonate in the bath fluid for hemodialysis. Trans Amer Soc Artif Int Organs 1964; 10: 110–3.

Novello A. , Kelsch R.C. , Easterling R.E. Acetate intolerance during hemodialysis. Clin Nephrol 1976; 5: 29–32.

Port F.K. , Easterling R.E. Evaluation of acetate tolerance during highly efficient hemodialysis. Proc Dial Transplant Forum 1975; 5: 128–30.

Nagai K. , Pagel M. , Rattazzi T. , Vizzo J. , Scribner B.H. The influence of acetate versus bicarbonate on patient symptomatology during dialysis. Proc Eur Dial Transplant Assoc 1979; 16: 122–8.

Mansell M.A. , Nunan T.O. , Laker M.F. , Boon N.A. , Wing A.J. Incidence and significance of rising blood acetate levels during hemodialysis. Clin Nephrol 1979; 12: 22–5.

Aizawa Y. , Ohmori I. , Imai K. , Matsuoka M. , Hirasawa Y. Depressent effect of acetate upon the human cardiovascular system. Clin Nephrol 1977; 8: 477–80.

Pagel M.D. , Ahmad S. , Vizzo J.E. , Scribner B.H. Acetate and bicarbonate fluctuations and acetate intolerance during dialysis. Kidney Int 1982; 21: 513–8.

Graefe U. , Milutinovich J. , Follette W.C. , Vizzo J.E. , Babb A.L. , Scribner B.H. Less dialysis-induced morbidity and vascular instability with bicarbonate in dialysate. Ann Intern Med 1978; 88: 332–6.

Man N.K. , Fournier G. , Thireau P. , Gaillard J.L. , Funck-Brentano J.L. Effect of bicarbonate-containing dialysate on chronic hemodialysis patients: a comparative study. Int Soc Artif Intern Organs 1982; 6: 421–5.

Vanholder R. , Piron M. , Ringoir S. Absence of a beneficial haemodynamic effect of bicarbonate versus acetate haemodialysis. Proc EDTA-ERA 1984; 21: 195–201.

Mastrangelo F. , Rizzelli S. , Corliano C. Benefits of bicarbonate dialysis. Kidney Int 1985; 28(Suppl 17): S188–93.

Collins A. , Ilstrup K. , Hanson G. , Berkseth R. , Keshaviah P. Rapid high-efficiency hemodialysis. Artif Organs 1986; 10: 185–8.

La Greca G. , Feriani M. , Bragantini L. , Petrosino L. , Santoro A. , Altieri P. Effects of acetate and bicarbonate dialysate on vascular stability: a prospective multicenter study. Int J Artif Organs 1987; 10: 157–62.

Malberti F. , Surian M. , Colussi G. , Minetti L. The influence of dialysis fluid composition on dialysis tolerance. Nephrol Dial Transplant 1987; 2: 93–8.

Oettinger C.W. , Oliver J.C. An economical new process for incenter bicarbonate dialysate production: comparison with acetate in a large dialysis population. Artif Organs 1989; 13: 432–7.

Henrich W.L. , Woodard T.D. , Meyer B.D. , Chappell T.R. , Rubin L.J. High sodium bicarbonate and acetate hemodialysis: double-blind crossover comparison of hemodynamic and ventilatory effects. Kidney Int 1983; 24: 240–5.

Leenen F.H.H. , Buda A.J. , Smith D.L. , Farrell S. , Levine D.Z. , Uldall P.R. Hemodynamic changes during acetate and bicarbonate hemodialysis. Artif Organs 1984; 8: 411–7.

Nissenson A.R. Prevention of dialysis-induced hypoxemia by bicarbonate dialysis. Trans Am Soc Artif Inter Organs 1980; 26: 339–42.

Mansell M.A. , Morgan S.H. , Moore R.M. , Kong C.H. , Laker M.F. , Wing A.J. Cardiovascular and acid-base effects of acetate and bicarbonate haemodialysis. Nephrol Dial Transplant 1987; 1: 229–32.

Velez R.L. , Woodard T.D. , Henrich W.L. Acetate and bicarbonate hemodialysis in patients with and without autonomic dysfunction. Kidney Int 1984; 26: 59–65.

Hampl H. , Klopp H.W. , Michels N. Electroencephalogram investigations of the disequilibrium syndrome during bicarbonate and acetate dialysis. Proc EDTA 1982; 19: 351–9.

Iseki K. , Onoyama K. , Maeda T. Comparison of hemodynamics induced by conventional acetate hemodialysis, bicarbonate hemodialysis and ultrafiltration. Clin Nephrol 1980; 14: 294–8.

Leunissen K.M.L. , Hoorntje S.J. , Fiers H.A. , Dekkers W.T. , Mulder A.W. Acetate versus bicarbonate in critically ill patients. Nephron 1986; 42: 146–51.

Graefe U. , Milutinovich J. , Follette W.C. , Babb A.L. , Scribner B.H. Improved tolerance to rapid ultrafiltration with the use of bicarbonate in dialysate. Proc EDTA 1977; 14: 153–9.

Hsu C.H. , Swartz R.D. , Somermeyer M.G. , Raj A. Bicarbonate hemodialysis: influence on plasma refilling and hemodynamic stability. Nephron 1984; 38: 202–8.

Borges H. , Fryd D. , Kjellstrand C. Bicarbonate is not better than acetate in acute dialysis. Kidney Int 1981; 19: 144.

Wehle B. , Asaba H. , Castenfors J. The influence of dialysis fluid composition on the blood pressure response to dialysis. Clin Nephrol 1978; 10: 62–6.

Otte K.E. , Lillevang S.T. , Rasmussen A.G. , Christensen H.K. , Pedersen F.B. Acetate or bicarbonate for haemodialysis: a randomised, double-blind controlled trial. Nephrol Dial Transplant 1990; 5: 931–6.

Leunissen K.M.L. , Claessens P.J.M. , Mooy J.M.V. , van Hoof J.P. , Shaldon S. Chronic haemodialysis with bicarbonate dialysate. Technical and clinical aspects. Blood Purif 1990; 8: 347–58.

Ward R.A. Acid-base homeostasis in dialysis patients. In: Nissenson A.R. , Fine R.N. , Gentile D.E. , eds. Clinical dialysis. Norwalk: Appleton & Lange, 1990; 330–49.

Port F.K. Fluid and electrolyte disorders in dialysis. In: Kokko J.P. , Tannen R.L. , eds. Fluids and electrolytes. Philadelphia: W B Saunders, 1990; 747–80.

Stewart W.K. The composition of dialysis fluid. In: Maher J.F. , ed. Replacement of renal function by dialysis: a textbook of dialysis. Dordrecht: Kluwer Academic Publishers, 1989; 199–217.

Diamond S.M. , Henrich W.L. Acetate dialysate versus bicarbonate dialysate: a continuing controversy. Am J Kidney Dis 1987; 9: 3–11.

Maggiore Q. , Enia G. , Catalano C. , Polimeni R.M. Bicarbonate dialysis-CON. Int J Artif Organs 1987; 10: 151–6.

Mastrangelo F. Bicarbonate dialysis-PRO. Int J Artif Organs 1987; 10: 145–50.

Mansell M.A. , Wing A.J. Acetate or bicarbonate for haemodialysis? Br Med J 1983; 287: 308–9.

Heneghan W.F. Acetate, bicarbonate and hypotension during hemodialysis. Am J Kidney Dis 1982; 2: 302–4.

Duarte R.R. The rebirth of bicarbonate. Int J Artif Org 1983; 6: 57–9.

Novello A.C. Pandora's box revisited: a second look at the acetate story. Int J Artif Organs 1980; 3: 255–7.

Veech R.L. The untoward effects of the anions of dialysis fluids. Kidney Int 1988; 34: 587–97.

Slatopolsky E. , Bricker N.S. The role of phosphorus restriction in the prevention of secondary hyperparathyroidism in chronic renal disease. Kidney Int 1973; 4: 141–5.

Lefebvre A. , DeVernejoul M.C. , Gueris J. Optimal correction of acidosis changes progression of dialysis osteodystrophy. Kidney Int 1989; 36: 1112–8.

Mastrangelo F. , Rizzelli S. , De Blasi V. Favourable effects of bicarbonate dialysis on the body pool of phosphate. Proc EDTA-ERA 1984; 21: 215–20.

Hara Y. , May R.C. , Kelly R.A. , Mitch W.E. Acidosis, not azotemia, stimulates branches-chain, amino acid catabolism in uremic rats. Kidney Int 1987; 32: 808–14.

Hultman E. , Del Canale S. , Sjoholm H. Effect of induced metabolic acidosis on intracellular pH buffer capacity and contraction force of human skeletal muscle. Clin Sci 1985; 69: 505–10.

Brenes L.G. , Brenes J.N. , Hernandez M.M. Familial proximal renal tubular acidosis. A distinct clinical entity. Am J Med 1977; 63: 244–52.

Gonzales F.M. , Pearson J.E. , Garbus S.B. On the effects of acetate during hemodialysis. Trans Am Soc Artif Intern Organs 1974; 20: 169–74.

Tsaltas T.T. , Friedman E.A. Plasma lipid studies of uremic patients during hemodialysis. Am J Clin Nutr 1968; 21: 430–5.

Bingel M. , Lonnemann G. , Koch K.M. , Dinarello C.A. , Shaldon S. Enhancement of in vitro human interleukin-1 production by sodium acetate. Lancet 1987; ii: 14–6.

Seyffart G. , Ensminger A. , Scholz R. Increase of body mass during long-term bicarbonate hemodialysis. Kidney Int 1987; 32(Suppl. 22): S174–7.

Kishimoto T. Quantity and quality of end stage renal disease treatment around the world. In: Klinkmann Smegy , eds. Contrib Nephrol, vol. 78: Terminal renal failure: therapeutic problems, possibilities and potentials. Basel: Karger, 1990.