Treatment of Hepatic Insufficiency Based on Cellular Therapies

Miyazaki K. , Takaki R. , Nakayama F. Isolation and primary culture of adult human hepatocytes. Ultrastructural and functional studies. Cell Tissue Res 1981; 218: 13–21.

Santone K.S. , Acosta D. , Stauchansky S.A. , Bruckner J.V. The use of primary cultures of postnatal rat hepatocytes to investigate carbon-tetrachloride cytotoxicity. In: Guil-louzo A. , ed. Liver cells and drugs. London: J Libbey, 1988; 221–32.

Leffert H. , Paul D. Serum dependent growth of primary cultured differentiated fetal rat hepatocytes in arguine-deficient medium. J Cell Physiol 1973; 81: 113–24.

Jones E.A. , Schaefer D.F. Fulminant helpatic failure. In: Zakim D. , Boyer T.D. , eds. Hepatology. Philadelphia: WB Saunders, 1990; 460–75.

Jauregui H.O. , Naik S. , Santangini H. Diazepam metabolism in perfused cultures of adult rat hepatocytes. In: Butterworth RF, Layrargues GP, eds. Hepatic encephalopathy. Pathogenesis and treatment. Clifton NJ: Humana Press Inc, 1989; 339: 251.

Naik S. , Santangini H. , Jauregui H.O. Culture of adult rabbit hepatocytes in perfused hollow membranes. In Vitro 1990; 263: 107.

Wilson J.M. , Jefferson D.M. , Chowdhury J.R. , Novikoff P.M. , Johnston D.E. , Mulligan R.C. Retrovirus-mediated transduction of adult hepatocytes. Proc Natl Acad Sci USA 1988; 85: 3014–8.

Wolff J.A. , Yee T.K. , Skelly H.F. Expression of retrovirally transduced genes in primary cultures of adult rat hepatocytes. Proc Natl Sci USA 1987; 84: 3344–8.

Ledley F.D. , Darlington G.J. , Hahn T. , Woo S.L. Retroviral gene transfer into primary hepatocytes: Implications for genetic therapy of liver-specific functions. Proc Natl Sci USA 1987; 84: 5335–9.

Wu C.H. , Wilson J.W. , Wu C.Y. Targeting genes. Delivery and persistent expression of a foreign gene driven by mammalian regulation elements in vivo. J Biol Chem 1989; 264: 16985–7.

Nakamura T. , Yoshimoto K. , Nakayama Y. , Tomita Y. , Ichihara A. Reciprocal modulation of growth and differentiated functions of mature rat hepatocytes in primary culture by cell-cell contact and cell membranes. Proc Natl Aca Sci USA 1983; 80: 7229–33.

Wolf C.F.W. , Mulkelt B.E. , Kaighn M.E. The conjugation of bilirubin by rat hepatoma cells in tissue culture. Proc Soc Exp Biol Med 1974; 145: 918–24.

Guzelian P.S. , Diegelman R.F. Retention of clostridial collagenase by primary cultures of parenchymal cells prepared from adult rat liver. Life Sci 1979; 24: 513–8.

Jauregui H.O. , McMillan P.N. , Hevey K. , Naik S. A quantitative analysis of lectin binding to adult rat hepatocyte cell surfaces. In Vitro 1988; 24: 401–12.

McMillan P.N. , Hevey K.A. , Hixson D.C. , Naik S. , Jauregui H.O. Hepatocyte cell surface polarity as demonstrated by lectin binding to isolated and cultured hepatocytes. J Histochem Cytochem 1988; 36: 1561–71.

Gumucio J.J. , May M. , Dvorak C. , Chianale J. , Massey V. The isolation of functionally heterogeneous hepatocytes of the proximal and distal half of the liver acinus in the rat. Hepatology 1986; 6: 932–44.

Chianale J. , Dvorak C. , May M. , Gumucio Heterogeneous expression of phenobarbital-inducible cytochrome P-450 genes within the hepatic acinus in the rat. Hepatology 1986; 6: 945–51.

Ben-Ze'ev A. , Robinson G.S. , Bucher N.L.R. , Farmer S.R. Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes. Proc Natl Acad Sci USA 1988; 85: 2161–5.

Guguen-Guillouzo C. , Clement B. , Battet G. Maintenance and reversibility of active albumin secretion by adult rat hepatocytes co-cultured with another liver epithelial cell type. Exp Cell Res 1983; 143: 47–54.

Morin O. , Normand C. Long-term maintenance of hepatocyte functional activity in co-culture: requirements for sinusoidal endothelial cells and dexamethasone. J of Cellular Phys 1986; 129: 103–10.

Koide N. , Sakaguchi K. , Koide Y. Formation of multicellular spheroids composed of adult rat hepatocytes in dishes with positively charged surfaces and under other nonadherent environments. Exp Cell Res 1990; 186: 227–35.

Matas A.J. , Sutherland D.E.R. , Steffes M.W. Transplantation of liver cells in an animal model of congenital enzyme deficiency disease: the Gunn rat. Transplant Proc 1977; 1: 313–6.

Demetriou A.A. , Whiting J.F. , Feldman D. Replacement of liver function in rats by transplantation of microcarrier-attached hepatocytes. Science 1986; 233: 1190–2.

Saunders S.J. Experimental models of hepatic failure. In: Hepatology. Freigberg: Germany Fulk Foundation, 1979; 37–46.

Geller D. , Gammal S.H. , Mullen K.D. An improved rat model of hepatic encephalopathy due to fulminant hepatic failure. The importance of supportive therapy. In: Soeters P.B. , Wilson J.H.P. , Meijer A.J. , eds. Advances in ammonia metabolism and hepatic encephalopathy. Amsterdam: Excerpta Medica, 1988; 213–7.

Gerlach J. , Kloppel K. , Schauwecker H.H. , Tauber R. , Muller Ch , Bucherl ES. Use of hepatocytes in adhesion and suspension cultures for liver support bioreactors. Int J Artif Organs 1989; 12: 788–92.

Bassett M.L. , Mullen K.D. , Skolnick P. , Jones E.A. Amelioration of hepatic encephalopathy by pharmacological antagonism of the GABA_A/benzodiazepine receptor complex in a rabbit model of fulminant hepatic failure. Gastroenterology 1987; 93: 1069–77.

Krebs H.A. , Lund P. , Edwards M. Criteria of metabolic competence of isolated hepatocytes. In: Reid E. , ed. Cell populations. UK: Ellis Horwod Ltd, 1979; 1–6.

Jauregui H.O. , Hayner N.T. , Driscoll J.L. , Williams-Holland R. , Lipsky M.H. , Galletti P.M. Trypan blue dye uptake and lactate dehyrogenase in adult rat hepatocytes - freshly isolated cells, cell suspensions, and primary monolayer cultures. In Vitro 1981; 17: 1100–10.

Guzelian P.S. , Bissell D.M. , Mayer U.A. Drug metabolism in adult rat hepatocytes in primary monolayer culture. Gastroenterology 1977; 72: 1232–9.

Guengerich F.B. Enzymology of rat liver cytochrome P-450. In: Guengerich FB, ed. Mammalian cytochromes P-450. Boco Raton: CRC Press Inc, 1987; 1: 2–54.

Distlerath L.M. , Guengerich F.B. Enzymology of human liver cytochrome P-450. In: Guengerich FB, ed. Mammalian cytochromes P-450. Boco Raton: CRC Press Inc, 1987; 1: 133–98.

Ziegler D.M. Detoxification: oxidation and reduction. In: Arias IM, Jakoby WB, Popper H, Schachter D, Shafritz DA, eds. The liver: biology and pathobiology. New York: Raven Press Ltd, 1988; 2: 363–74.

Baraldi M. , Zeneroli M.L. , Ventura E. Supersensitivity of benzodiazepine receptors in hepatic encephalopathy due to fulminant hepatic failure in the rat: reversal by a benzodiazepine antagonist. Clin Sci 1984; 67: 167–75.

Jauregui H.O. , Ng S. , Gann K. , Waxman D.J. Xenobiotic induction of P-450 PB-4 (II B1) and P-450c (IA1) and associated monooxigenase activities in primary cultures of adult rat hepatocytes. Xenobiotica (in press).

Reilly P.E.B. , Thompson D.A. , Mason S. , Hooper W.D. Cytochrome P40IIIA enzymes in rat liver microsomes: Involvement in C₃-hydroxylation of diazepam and nor-dazepam but not N-dealkylation of diazepam and te-mazepam. Mol Pharmacol 1990; 37: 767–74.

Caron J.M. , Bissell D.M. Extracellular matrix induces albumin gene expression in cultured rat hepatocytes. Hepatology 1989; 100: 636.