Long-term Increase in Peritoneal Membrane Transport Rates following Incidental Intraperitoneal Sodium Hypochlorite Infusion

Abstract

A patient on continuous ambulatory peritoneal dialysis using an “O” set connection system with sodium hypochlorite as a disinfectant incidentally infused the disinfectant intraperitoneally on two occasions. The product of peritoneal membrane permeability and peritoneal membrane surface area increased after both infusions as judged by peritoneal equilibration test results and/or serum chemistries. Elevated peritoneal solute transport rates and reduced ultrafiltration gradually subsided but did not return to preinfusion values. This observation suggests that intraperitoneal sodium hypochlorite infusion may cause significant long-term alteration in peritoneal membrane transport characteristics.