Abstract
A new insulin delivery system Vitajet™ has been invented which involves a high-pressure spring and obviates the use of needle injections. To study its efficacy we compared blood glucose fluctuations, integrated glycemia, free insulin and total free insulin concentrations in six insulin-dependent diabetics. After obtaining a steady state of carbohydrate metabolism overnight by feedback control through the artificial endocrine pancreas (AEP) Bios-tator, the patients received their usual morning and evening doses of insulin by either conventional injection or Vitajet in random order. Blood glucose levels were significantly lower after Vitajet than conventional injections (p< 0.04) between 10 a.m. and 4 p.m., but the difference disappeared from 4 p.m. onwards. The areas under the curve (AUCs) of glucose fluctuations were lower after Vitajet (28036± 4655 vs 31086± 2310 mg. min% mean±SEM, p< 0.01). AUCs for free insulin concentrations (μU.min/ml) were close: 39286± 4510 (Vitajet) vs 30597± 3575 (conventional).
It is concluded that Vitajet constitutes an efficient needleless route for administering insulin pulses. (Int J Artif Organs 1989;12:333-8)
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