A thrombotic microangiopathy syndrome, clinically and pathologically similar to thrombotic thrombocytopenic purpura (TTP) has been reported in recipients of tissue transplants, including renal and bone marrow allografts. The diagnosis is made only after other causes of microangiopathic hemolytic anemia have been excluded. In this case report we present the outcome of the combination of plasma exchange, dipyridamole and aspirin in the management of a TTP-like syndrome that complicated the post-operative course of liver transplantation.
ValbonesiM., GarelliS., MontaniF., CefisM., FlorioG.A simple and rapid test for the quantification of osmotic fragility of red blood cells.Acta Haemat1983; 69: 106–10.
5.
SheldonR., SlaughterD.A syndrome of microangiopathic hemolytic anemia, renal impairment, and pulmonary edema in chemotherapy-treated patients with adenocarcinoma.Cancer1986; 58: 1428–36.
6.
DeGroenP.C., AksamitA.J., RakelaJ., ForbesG.S., KromR.A.F.Central nervous system toxicity after liver transplantation.N Engl J Med1987; 317: 861–6.
7.
RidolphiR.L., BellW.R.Thrombotic thrombocytopenic purpura. Report of 25 cases and review of the literature.Medicine1981: 60: 413–24.
8.
CuttnerJ.Thrombotic thrombocytopenic purpura: a ten-year experience.Blood1980; 56: 302–6.
9.
ZimmermanS.E., SmithF.P., PhillipsT.M., CoffeyR.J., ScheinP.S.Gastric carcinoma and thrombotic thrombocytopenic purpura: association with plasma immune complex concentrations.Br Med J1982; 284: 1432–4.
10.
AtkinsonK., BiggsJ.C., HayeJ.Cyclosporin A associated nephrotoxicity in the first 100 days after allogeneic bone marrow transplantation: Three distinct syndromes.Br J Haematol1983; 54: 59–67.
11.
KwaanH.C.Miscellaneous secondary thrombotic microangiopathy.Seminars in Hematol1987; 24: 141–7.