Serum prolactin (PRL) levels are elevated in patients with chronic renal failure (CRF) but the mechanisms responsible for these abnormalities are not fully understood. PRL secretion is undoubtedly influenced by many substances, which can be variously altered in uremia: monoamines, endogenous opiates and PTH. Our data suggest that in early renal failure PRL levels are already significantly high and the 24-h pattern of PRL secretion is significantly different from that in controls.
PRL derangements could be due in mild renal failure, to unknown factors (GABA?); in severe CRF, to a major change in dopaminergic activity; in hemodialysis (HD), to a low turnover of monoamines, and in peritoneal dialysis (PD) to increased activity of sero-toninergic and dopaminergic systems.
NagelI.C., FreinkelN., BellR.H., FriesenH., WilberJ.F., MetzgerB.E.Gynecomastia, prolactin and other peptide hormones in patients undergoing chronic hemodialysis. J Clin Endocr1973; 35: 428–33.
2.
HagenC., OlgaardK., McNeillyA.S., FisherR.Prolactin and the pituitary-gonadal axis in male uraemic patients on regular dialysis. Acta Endocrinologia1976; 82: 29–33.
3.
MassryS.G., GoldsteinD.A., ProcciW.R., KletskyO.A.On the pathogenesis of sexual dysfunction of the uraemic male. Proc Eur Dial Transpl Ass1980; 17: 139–45.
4.
MassryS.G., GoldsteinD.A., ProcciW.R., KletskyO.A.Impotence in patients with uremia: A possible role for parathyroid hormone. Nephron1977; 19: 305–19.
5.
ProcciS.R., GoldsteinD.A., AdelsteinJ., MassryS.G.Sexual dysfunction in the male patient with uremia. A reappraisal. Kidney Int1981; 19: 317–23.
GrzeszczakW., KokotF., DulawaJ.Influence of naloxone on prolactin secretion in patients with acute and chronic renal failure. Clin Nephrology1984; 21: 47–9.
8.
DunnJ.D., ArimuraA., SchevingL.E.Effect of stress on circadian periodicity in serum LH and prolactin concentrations. Endrocrinology1972; 90: 29–33.
9.
AgneseG.Sui metodi statistici per lo studio delle oscillazioni endemiche. Igiene mod1956; 49: 385–97.
10.
BlissC.I.Periodic regression in biology and climatology. The Connecticut Agricultural Experimental Station, Bull. 615. New Haven, Conn 1958; p.i.
11.
HalbergF., TongY.L., JohnsonE.A.Circadian system phase, an aspect of temporal morphology; procedures and illustrative examples. Proc International Congress of Anatomists. In: The cellular aspect of biorhythms, Symposium on Biorhythms, Springer Verlag, 1967; 20–48.
12.
FranzA.G.The regulation of prolactin secretion in humans. In: GanongW.F., MartiniL., eds. Frontiers in Neu-roendocrinology 1973.New York: Oxford University Press, 1973; 337–74.
13.
LimV.S., KathpaliaS.C., FrohmanL.A.Hyperprolactinemia and impaired pituitary response to suppression and stimulation in CRF. J Clin Endocr Metab1979; 48: 101–7.
14.
KokotF., MleczkoZ., PazeraA.PTH and PRL and function of the pituitary gonadal axis in male patients with ARF. Kidney Int1982; 21: 84–9.
15.
BiasioliS., D'AndreaG., ChiaramonteS.The role of neurotransmitters in the genesis of uremic encephalopathy. Int J Art Organs1984; 7: 101–6.
16.
De BesiL., DelitaliaG., SerafiniE.Indirect evaluation of the opiod tone in uremic patients on HD. Bari Seminars in Nephrology (March 29-30-31, 1984), Abstract Book, page 24.
17.
VolpeA., Di RenzoG.C., MontanariG.D.Variazioni e ritmi della prolattina in fisiologia. J Endocrinol Invest1980; 3(suppl. 2): 35–9.
18.
NokinJ., VekemansM., L'HermiteM., RobynC.Circadian periodicity of serum prolactin concentration in man. Brit Med J1972; 3: 561–2.
19.
SassinJ.F., FrantzA.G., WeitzmanE.D., KapensS.Human prolactin with increased release during sleep. Science1972; 177: 1205–7.
20.
ParkerD.C., RossmanL.G., VanderlaanE.F.Sleep-related nycthemeral and briefly episodic variation in human plasma PRL concentrations. J Clin Endocr1973; 37: 1119–24.
21.
Perez-LopezF.R., RobynC.Studies in human prolactin physiology. Life Sci1974; 15: 599–616.
22.
ParkerDC, RossmanL.G., Vander LaanE.F.Relation of sleep-entrained human prolactin release to REM-non REM cycles. J Clin Endocrinol Metab1974; 58: 646–50.
23.
PolleriA., BarrecaT., CicchettiV., GianrossiR., MasturzoP., RolandiE.The 24-H pattern of human prolactin in serum. Chronobiologia1976; 3: 27–33.
24.
JouvetM.Biogenetic amines and the status of sleep. Science1972; 163: 32–41.
25.
MendelsonW.B., JacobsL.S., ReichmanJ.D.Methy-sergide. Suppression of sleep-related prolactin secretion and enhancement of sleep-related growth hormone secretion. J Clin Invest1975; 56: 690–7.
26.
ScapagniniU., GerendaiI., ClementiG., FioreL., MarchettiB., PratoA.Role of brain monoamines in the regulation of the circadian variations of activitiy of some neuroen-drocrine axes. In: AssenmacherI., FarnerD.S., eds: Environmental endocrinology.Berlin: Springer, 1978; 137–43.
27.
PyeI.F., Mc GaleE.H.F., StonierC., HutchinsonE.C., AberG.M.Studies of cerebrospinal fluid and plasma AA in patients with steady chronic renal failure. Clinical Chimica Acta1979; 92: 65–72.
28.
De FerrariG., GaribottoG., RobaudoC., GhiggeriG.M., Ti-zianelloA.Brain metabolism of amino acids and ammonia in patients with chronic renal insufficiency. Kidney Int.1981; 20: 505–10.
29.
BiasioliS., ChiaramonteS., FabrisA.Neurotransmitter imbalance in plasma and cerebrospinal fluid during dialytic treatment. Trans ASAIO1983; XXIX: 44–9.
30.
BiasioliS., D'AndreaG., FabrisA., FerianiM., La GrecaG.The pathogenesis of uremic encephalopathy. Int J Art Organs1985; 8: 59–60.
31.
BarsottiG., CiardellaF., FiorettiP.Plasma Prolactin (PRL) and Testosterone (T) levels in uremics treated with hemodialysis on very low protein diet. Bari Seminars in Nephrology (March 29-30-31, 1984), Abstract book, page 8.
32.
IsaiaG.C., GhigoE., MaccarioM.Impaired PRL and TSH responses to antidopaminergic drugs and to TRH in patients with CRF. Bari Seminars in Nephrology (March 29-30-31, 1984), Abstract book, page 48.
33.
LunettaM., InfantoneE., MughiniL.Hyperprolactinemia in uraemic patients. Effect of sulpiride, bromocriptine and insulin-induced hypoglycaemia. Bari Seminars in Nephrology (March 29-30-31, 1984), Abstract book, page 52.
