Serum ferroxidase I (ceruloplasmin) and ferroxidase II activities were studied in 49 uremic patients under conservative treatment, in 79 patients undergoing hemodialysis and in 56 healthy subjects, as controls. Ferroxidase I was significantly higher in both groups of patients. Ferroxidase II was significantly elevated only in patients undergoing chronic hemodialysis. The cause of this difference is not clear, but seems to be of considerable interest.
OsakiS., JohnsonD.A., FriedenE.The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J Biol Chem1966; 241: 2746–51.
2.
McDermottI.A., HuberC.T., OsakiS., FriedenE.Role of iron in the oxidase activity of ceruloplasmin. Biochem Biophys Acta1968; 151: 541–57.
3.
MasonK.E.Copper metabolism and requirements of man. J Nutr1979; 109: 1979–2066.
FriedenE.The ferrous to ferric cycles in iron metabolism. Nutr Rev1973; 31: 41–4.
6.
HsiehH.S., FriedenE.Evidence for ceruloplasmin as a copper transport protein. Biochem Biophys Res Comm1975; 67: 1326–31.
7.
OsakiS., McDermottJ.A., FriedenE.Proof for the ascorbate activity of ceruloplasmin. J Biol Chem1964; 239: 3570–5.
8.
TophamR.W., FriedenE.Identification and purification of a non-ceruloplasmin ferroxidase of human serum. J Biol Chem1970; 245: 6698–705.
9.
GarnierA., TosiI., SteinbuchM.Ferroxidase II. The essential role of copper in enzymatic activity. Biochem Biophys Res Comm1981; 98: 66–71.
10.
RiceE.W.Correlation between serum copper, ceruloplasmin activity and C-reactive protein. Clin Chim Acta1960; 5: 632–6.
11.
SchenkerJ.G., JungreisE., PolishukW.Z.Oral contraceptives and correlation between serum copper and ceruloplasmin levels. Int J Fert1972; 17: 28–32.
12.
MoakS.A., GreenwaldR.A.Enhancement of rat serum ceruloplasmin levels by exposure to hyperoxia. Proc Soc Exp Biol Med1984; 177: 97–103.
13.
TsukamotoY., IwanamiS., MarumoF.Disturbances of trace element concentrations in plasma of patients with chronic renal failure. Nephron1980; 26: 174–9.
14.
BustamanteJ., Martin MateoM.C., De Paula de PedroA., Ortiz ManchadoD.Changes in copper and ceruloplasmin in chronic renal insufficiency treated by hemodialysis and peritoneal dialysis. Nephron1978; 22: 312–5.
15.
BergstromJ., FurstP.Uremic toxins, In: DrukkerW., ParsonsF.M., MaherI.F., eds. Replacement of renal function by dialysis.Boston: Martinus Nijhoff, 1983; 354–90.
16.
FeldmanH.A., SingerI.Endrocrinology and metabolism in uremia and dialysis. A clinical review. Medicine1975; 54: 345–76.
17.
RoeserH.P.The role of ascorbic acid in the turnover of storage iron. Semin Hematol1983; 20: 91–100.
18.
CohenN.L., KeenC.L., LönnerdalB., HurleyL.S.Effects of varying dietary iron on the expression of copper deficiency in the growing rat.: Anemia, ferroxidase I and II, tissue trace elements, ascorbic and xanthine dehydrogenase. J Nutr1985; 115: 663–9.
19.
PapastephanidisC., AgroyannisB., Tzanatos-ExarchouH.Re-evaluation of ascorbic acid deficiency in hemodialysed patients (under consideration in Int J Artif Organs).
20.
HuberC.T., FriedenE.The inhibition of ferroxidase by trivalent and other metal ions. J Biol Chem1970; 245: 3979–84.
21.
HuberC.T., FriedenE.Substrate activation and the kinetics of ferroxidase. J Biol Chem1970; 245: 3973–8.
22.
Frangos-PlemenosM., YatzidisH.A new method for direct specific measurement of ferroxidase I and II in serum (submitted).
