In 92 uremic patients under chronic hemodialysis without ascorbic acid supplementation, serum ascorbic acid was measured before hemodialysis and between two sessions. The results indicated a more serious ascorbic acid deficiency of patients than in previous studies. This difference might be explained by the highly specific enzymatic method applied in the present study, excluding any potential interference of various serum reducing substances.
LiuT.Z., ChinN., KiserM.D., BiglerW.N.Specific spectophotometry of ascorbic acid in serum or plasma by use of ascorbate oxidase. Clin Chem1982; 28: 2225–8.
2.
MarumoG., KamataK., OkuboM.Deranged concentrations of water-soluble vitamins in the blood of undialysed and dialysed patients with chronic renal failure. Intern J Artif Organs1986; 9: 17–24.
3.
SullivanJ.D., EisensteinA.B.Ascorbic acid depletion in patients undergoing chronic hemodialysis. Am J Clin Nutr1970; 23: 1339–46.
4.
SullivanJ.D., EisensteinA.B.Ascorbic acid depletion during hemodialysis. JAMA1972; 220: 1697–9.
5.
PönkaA., KuhlbäckB.Serum ascorbic acid in patients undergoing chronic hemodialysis. Acta Med Scand1983; 213: 305–7.
6.
TsapasG., MagoulaL., PaletaK., ConcourisL.Effect of peritoneal dialysis on plasma levels of ascorbic acid. Nephron1983; 33: 34–7.
7.
GrossiC., CoratelliP., PellegriniL.Paradoxical variations of L-ascorbatemia during acetate hemodialysis. Abstracts EDTA1983; 20: 53.
8.
SamynW.“True” ascorbic acid in plasma and serum: investigation of a new method. Clin Chim Acta1983; 133: 111–7.
9.
JaffeG.N.Vitamin C. In: MachlinL.J., ed. Handbook of vitamins. Nutritional Biochemical and Clinical Aspects.New York: Marcel Dekker Inc, 1984; 199–244.
10.
CoxE.V., MeynellM.J., NorthamB.E., CookeW.T.The anaemia of scurvy. Am J Med1967; 42: 220–7.
11.
KrumbiectC., ButterworthC.Ascorbate-cholesterolecithin interactions: factors of potential importance in the pathogenesis of atherosclerosis. Am J Clin Nutr1974; 27: 866–76.
12.
AckermanR.A., ColesJ.S.Effective reduction of chloramine levels in dialysate. Dial Transpl1982; 11: 976–7.
13.
NeilanB.A., EhlersS.M., KoplinC.F.Prevention of chloramine-induced hemodialysis in dialyzed patients. Clin Nephrol1978; 12: 103–8.
14.
PruC., EatonJ., KjellstrandC.Vitamin C may cause secondary oxalosis in chronic hemodialysis patients. Kidney Int1982; 21: 176.
15.
OrthopoulosB., Tzanatos-ExarchouE., PapastephanidisC.Serum oxalic acid in patients undergoing maintenance hemodialysis. Proceedings of 3rd Hellenic Congress of Nephrology1984; 391–9.
16.
MitwalliA., OreopoulosD.G.Hyperoxaluria and hyperoxalemia: one more concern for the nephrologist. Int J Artif Organs1985; 8: 71–4.
17.
PruC., EatonJ., KjellstrandC.Vitamin C intoxication and hyperoxalemia in chronic hemodialysis patients. Nephron1985; 39: 112–6.