Plasma Exchange with Prostaglandin I 2 and ACD Solution: Comparative Effects

Abstract

Discontinuous plasma exchange with prostaglandin I₂ (5ng/kg/min) and low dosage heparin (5-6 IU/kg/min) (treatment I), and ACD solution alone (treatment II) was studied. During both treatments the activated partial thromboplastin time remained within the normal range. After treatment I platelet count was not decreased but in vitro platelet aggregation was reduced (p < 0.001). After treatment II platelet count was reduced and in vitro platelet aggregation unchanged.

Prostaglandin I₂ at this dosage caused no cardiovascular complications. The physiopathological implications of these differences are discussed.