We studied the effects of one session of hemofiltration on the mineral metabolism in a group of uremic children. We observed an increase of calcemia, accompained by positive calcium balance, and a decrease of plasma phosphate and PTH-MM. No substantial loss of plasma 25-OH D was found. It is concluded that hemofiltration has a positive effect on calcemia and is very effective in removing phosphate, but it acts only temporarily on PTH removal.
An adequate calcium concentration must be provided in the substitution fluid.
SchaeferK., OffermannG., AsmusG., HerrathD.V.: Das Verhalten von Kalzium, Phosphat und Parathormon unter chronischer Hamofiltration.Nieren Hochdruckkr, 1978; 7, 40.
5.
QuellhorstE., ScheunemannB.: Metabolic and hemodynamic aspects of hemofiltration.Dial. and Transpl., 1978; 7, 369.
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ColtonC.K., HendersonL.W., FordC.A., LysaghtM.J.: Kinetics of hemodiafiltration. I. In vitro transport characteristic of a hollow-fiber blood ultrafilter.J. Lab. Clin. Med., 1975; 85, 355.
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Muller-WiefelD.E., KlareB., QuerfeldU., RauhW., ManzF., MehlsO., SchaererK.:: Hemofiltration in childhood.Renal insufficiency in children.Springer. Berlin1982.
8.
SargentJ., GotchF., BorahM., PiercY.L., SpimozziN., SchoenfeldP., HumphreysM.: Urea kinetics: a guide to nutritional management of renal failure.Am. J. Clin. Nutr., 1978; 31, 1696.
9.
BoschJ.P.: Calcium, phosphorus and PTH changes in hemofiltration.Proc. Hemofiltration: present status and prospects, vol. I, 234, Parma 1982.
10.
CecchettinM., AlbertiniA., ZoppiG., LindalA.W.: Radioimmunological methods in diagnosis of nutritional disturbances in infancy.Metabolic and Endocrinological Responses to Food Intake in Infancy.Karger., Basel1982.
11.
AksnesL.: Quantitation of the main metabolites of vitamin D in a single serum sample. I. Extraction, separation and purification of metabolites.Clin. Chim. Acta, 1980; 104, 133.
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AksnesL.: Quantitation of the main metabolites of vitamin D in a single serum sample.II. Determination by UV-absorption and competitive protein binding assay. Clin. Chim. Acta, 104, 147, 1980.
13.
CivatiG., GuastoniC., PeregoA., GalatoR., BrandoB., GrilloC., SurianM., ColussiG., TeatiniU., MinettiL.: Bilancio Ca-P e comportamento del PTH in 7 pazienti trattati con emofiltrazione integrale.Min. Nefr., 1981; 28, 171.
14.
NordinB.E.C.: Calcium, phosphate and magnesium metabolism.Churchill Livingstone. Edinburgh 1976.
15.
BettinelliA., BianchiM.L., AiminiE., OrtolaniS., SoldatiL., EdefontiA.: Effects of 1,25-dihydroxyvitamin—D3 treatment on mineral balance in children with end stage renal disease undergoing chronic hemofiltration.Pediatric Res. (in press).
16.
KramerP., MatthaeiD., FuchsC., ArnoldR., EbertR., McIntoshC., ScauderP., SchwinnG., SchelerF., LudwigH., SpittellerG.: Assessment of hormonal loss through hemofiltration.Artificial Organs, 1978; 2, 128.
