Abstract
Assuming that urea is distributed uniformly within the total body water, urea-space or total body fluid volume was determined in six uremic patients based on urea kinetics in hemofiltration.
The total body fluid volume before hemofiltration was 36.0 ± 3.6 L (61.8 ± 2.6% BW) and after hemofiltration 32.5 ± 3.4 L (59.3 ± 2.8% BW), suggesting that the total body fluid volume was nearly normalized by hemofiltration. It is concluded that urea-space, easily measurable based on urea kinetics during hemofiltration, is useful in evaluating the fluid balance in patients undergoing artificial kidney therapy.
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