Processing techniques using recycle and staging for blood cell collection lead to numerous conceptual design configurations. From a practical viewpoint, many of these schemes can become incongruous. Experimental fractional recoveries with up to six stages are presented, and material balance considerations and process comparisons are made. Isolation of specific leukocyte types, and cell viability effects are studied.
Van WieB.J., and SoferS.S.: Sedimentation Theory and Practical Considerations for the Design of Centrifugal Blood Cell Processes.IJAO, 7(4), 215, 1984.
2.
Van WieB.J., and SoferS.S.: The Effect of Recycle on the Continuous Centrifugal Processing of Blood Cells.IJAO, 8(1): 43, 1985.
3.
Van WieB.J., and SoferS.S.: Stagewise Separation to Improve Continuous Blood Cell Separators.IJAO, 8(1): 49, 1985.
4.
ItoY.: Flow-Through Centrifuge.Department of Health, Education and Welfare, PB-235559, 1976.
5.
AdamsD.A., U.S. Patent 3,586,413, 1971.
6.
DavidsonJ.D.: A Continuous Flow Separator for Use in Immunodepletion: Theory, Design and Experimental Observations. A thesis presented for the Master of Science degree at the University of Tennessee, Knoxville, December 1976.
7.
SartoryW.K.: Centrifuge Apparatus, U.S. Patent No. 3,957, 197, 1976.
8.
LolachiH.: Centrifugal Liquid Processing Apparatus. Baxter Travenol Laboratories, Inc., Deerfield, IL, United States Patent 4,113,173, 1978.
9.
WoltjesJ., ten DuisH.J., de JongJ.C.F., and WildevuurR.H.: Phagocytic Capacity of Neutrophilic Leucocytes: Standardization and Application of a Simple Technique. Paper presented at an ESAO meeting (European Society for Artificial Organs) 1978.
10.
GilcherR.O.: Personal Correspondance, Oklahoma Blood Institute, Oklahoma City, Oklahoma1982.
11.
SchoedorferD.: Haemonetics Corporation, Braintree, MD, Personal Correspondance1982.
12.
BuecheugerR., and BrownR.: Fenwal Laboratories, Division of Travenol Laboratories, Inc., Deerfield, IL. Personal Correspondence, 1981.
13.
CliftR.: Division of Oncology, University of Washington School of Medicine, and the Fred Hutchinson Cancer Research Center, Seattle, WA, Personal Correspondence, 1983.
14.
KolobowT.: Laboratory of Technical Development, National Heart, Blood and Lung Institute, Bethesda, Maryland, Personal Correspondence, 1978-1983.
15.
ItoY.: Laboratory of Technical Development, National Heart, Blood and Lung Institute, Bethesda, Maryland, Personal Correspondence 1978-1983.
16.
ItoY., SuaudeauJ., and BowmanR.L.: New Flow-Through Centrifuge Without Rotaing Seals Applied to Plasmapheresis, Science189: 999–1000, 1977.
17.
Van WieB.J.: Conceptualization and Evaluation of Techniques for Centrifugal Separation of Blood Cells: Optimum Process Conditions, Recycle, and Stagewise Processing, Ph.D. Thesis, University of Oklahoma, Norman, Oklahoma1982.
