Thyroid function was measured in 30 healthy subjects and 84 patients with various degrees of nephron loss (GRF: 70 ± 15 m/min, 30 ± 16 ml/min, 10 ± 7 ml/min and 2.1 ± 1.3 ml/min).
A low T3 and T4 syndrome is evident when GRF is reduced to 30 ± 16 ml/min while a blunted TSH response is detected earlier in the course of nephron loss. T3 response to TRH was normal and FT4 was not affected by renal dysfunction. The data indicate that in nephron loss hypothalamic-pituitary abnormalities occur.
ChopraI.J., ChopraU., SmithS.R., RezaM., SolomonD.H.: Reciprocal changes in serum concentrations of 3,3′,5′-Triiodothyronine (reverse T3 7 AND and 3,3′,5-Triiodothyronine (T3) in systemic illnesses.J. Clin. Endocrinol. Metab.41: 1043, 1975.
2.
CzekalskiS., MalczavaB., SobieszyczV., KozakA., EderM., GryczynskaM., BackzykK., KosowiczV.: Comparison of some circulating pituitary thyroid and gonodal hormone levels in non dialyzed and dialyzed males with chronic renal failure.Dial. Transpl.10: 438, 1981.
3.
CzernichowP., DauzetM.C., BroyerM., RappaportR.: Abnormal TSH PRL and GH response to TSH releasing factor in uremia.J. Clin. Endocrinol. Metab.43: 630, 1976.
4.
De SantoN.G., CarellaC., FineR., LeumannE., FineS., AmatoG., CapodicasaG., NuzziF., CapassoG., LamaG., ScoppaF., GiordanoC.: Data presented at Bari Seminars in Nephrology, March, 29-31, 1984.
5.
De SantoN.G., CarellaC., FineR., FineS., AmatoG., CapassoG., LamaG., ScoppaF., CapodicasaG., NuzziF., De SimoneV., GiordanoC.: Thyroid function in uremic children. Submitted to Kidney Int.
6.
FinucaneJ.F., GriffithsR.S., BlackE.G., HallC.L.: Effects of chronic renal disease on thyroid hormone metabolism.Acta Endocr.84: 750, 1977.
7.
GiordanoC., CarellaC., De SantoN.G., MioliV., BazzatoG., AmatoG., TarchiniA., ColiU., LandiniS.: Hormonal status in patients on CAPD and HD.Proc. 1st International Symposium on Peritoneal Dialysis, Wichtig, Milan, 394, 1982.
8.
GiordanoC., De SantoN.G., CarellaC., MioliV., BazzatoG., Di LeoV.A., AmatoG., TarchiniA., ColiU., LandiniS.: Thyroidal status in uremia Effects of hemodialysis and CAPD.Int. J. Artif. Organs5, 394, 1982.
9.
GiordanoC.: The biochemical basis of uremic toxicity.Int. J. Pediatr. Nephrol.3: 39–50, 1982.
10.
GiordanoC., De SantoN.G., CarellaC., MioliV., BazzatoG., AmatoG., Di LeoV.A., TarchiniG., ColiU., CapodicasaG., LandiniG., NuzziF., De SimoneV., EspositoA.: TSH response to TRH in hemodialysis and CAPD patients.Int. J. Artif. Organs7, 7, 1984.
11.
HasegawaK., MatsushitaY., OtomoS.: Abnormal response to thyrotrophin and growth hormone to thyrotrophon releasing hormone in chronic renal failure.Acta Endocr.79: 635, 1975.
12.
KapteinE.M., Mac IntyreS.S., WeinerJ.M., SpencerC.A., NicoloffJ.T.: Free thyroxene estimates in non thyroidal illness, Comparison of eight methods.J. Clin. Endocrinol Metab.52: 1073, 1981.
13.
KolendorfK., Broch MollerB., RogoskiP.: The influence of chronic renal failure on serum and urinary thyroid hormone levels.Acta Endocr.89: 90, 1978.
NogimoriT.A.: Clinical study on thyroid hormone secretion and metabolism in patients with chronic renal failure on hemodialysis. Folia Endocr.(Jap.)57: 903, 1981.
