Plasma and skeletal muscle free amino acids were measured in patients submitted to Hemodialysis (HD) or Continuous Ambulatory Peritoneal Dialysis (CAPD) in order to evaluate the effects of these different dialysis modalities on amino acid pools; the data were compared with those obtained in control subjects and in patients with advanced Chronic Renal Failure (CRF) not submitted to Regular Dialysis Treatment (RDT).
Our findings show low intracellular concentrations of VAL, total Branched Chain Amino Acid (BCAA) and TYR in uremic patients treated with CAPD but not in those undergoing HD.
The observed differences in muscle amino acid pattern could be well explained by a changed amino acid metabolism regulation in CAPD, possibly related to the sustained hyperinsulinism and to an increased rate of hepatic protein synthesis.
AlvestrandA., BergströmJ., FurstP.: Intracellular free amino acids in patients treated with regular hemodialysis.Proc. E.D.T.A.16, 179, 1979.
2.
AlvestrandA., FürstP., BergströmJ.: Plasma and muscle free aminoacids in uremia: influence of nutrition with aminoacids.Clin. Nephrol.18, 297, 1983.
3.
ArmstrongV.W., FuchsC., SchelerF.: Effect of dialysate glucose load on plasma glucose and insulin levels in CAPD-patients. In: (GahlG.H., KesselH., NolphK.D. eds.), Advances in peritoneal dialysis.Excerpta Medica, Amsterdam, 421, 1981.
4.
BergerM., ZimmermanT.H., BerchtoldP., DrostH., MüllerW.A., GriesF.A., ZimmermannH.: Blood amino acid levels in patients with insulin excess (functioning insulinomas) and insulin deficiency (diabetic ketosis).Metabolism,27, 793, 1978.
5.
BlumenkrantzM.J., KoppleJ.D., MoraJ.K., CoburnJ.W.: Metabolic balance studies and dietary protein requirements in patients undergoing CAPD.Kidney Int.,21, 849, 1982.
6.
De FronzoR.A., FeligP.: Amino acid metabolism in uremia: insights gained from normal and diabetic man.Am. J. Clin. Nutr.33, 1378, 1980.
7.
DombrosN., OrenA., MarlissE.B., AndersonG.H., SteinA.N., KhannaR., PetitJ., BrandesL., LeibelB.S., RodellaH., OreopoulosD.: Plasma amino acid profiles and amino acid losses in patients under CAPD.Perit. Dial. Bull.,2, 27, 1982.
8.
DurninJ.V., WomersleyJ.: Body fat assessed from total body density and its estimation from skinfold thickness: measurement in 481 men and women aged from 16 to 72 years.Br. J. Nutr,21, 681, 1967.
9.
FarrellP.C., HoneP.W.: Dialysis-induced catabolism.Am. J. Clin. Nutr.,33, 1417, 1980.
10.
FischerJ.E.: Amino acids in hepatic coma.Dig. dis. Sci.,27, 97, 1982.
11.
FrisanchoA.R.: New norms of upper limb fat and muscle areas for assessment of nutritional status.Am. J. Clin. Nutr.34, 2540, 1981.
12.
GiordanoC., De SantoN.G., CapodicasaG., Di LeoV.A., Di SerafinoG.: Amino acids losses during CAPD.Clin. Nephrol.,230, 232, 1980.
13.
HampersC.L., SoeldnerJ.S., DoakC.L., MerrillJ.P.: Effect of chronic renal failure and hemodialysis on carbohydrate metabolism.J. Clin. Invest.,45, 1719, 1966.
14.
HeatonA., JohnstonD.G., BurrinJ.M., OrskovH., WardM.K., AlbertiK.G., KerrD.N.: Carbohydrate and lipid metabolism during Continuous Ambulatory Peritoneal Dialysis (CAPD): the effect of a single dialysis cicle.Clin. Sci.65, 539, 1983.
15.
KoppleJ., SwendseitM.E.: Protein and aminoacid metabolism in uremic patients undergoing maintenance hemodialysis.Kidney Int.7, S64, 1975.
16.
KoppleJ.D., BlumenkrantzM.J., JonesM.R., MoranJ.K., CoburnJ.W.: Plasma amino acid levels and amino acid losses during CAPD.Am. J. Clin. Nutr.,36, 395, 1982.
17.
MontanariA., BorghiL., SimoniI., TrifiròA., GherardiS., EliaG.F., SaniE., NovariniA.: Plasma and muscle free amino acids in liver cirrhosis with ascites. Submitted to Am. J. Clin. Nutr.,1983.
18.
NovariniA., MontanariA., BorghiL., SimoniI., TrifiròA., NicolottiL., LugariR., GnudiA.: Plasma and muscle free amino acids in insulin-treated diabetes. Submitted to Diabetes, 1983.
19.
ShearL.: Internal redistribution of tissue protein synthesis in uremia.J. Clin. Invest.,48, 1252, 1969.
20.
YoungG.A., SwanepoelM.R., RobsonS.M., ParsonsS.M.: Anthropometry and plasma valine, aminoacids and proteins in the nutritional assessment of hemodialysis patients.Kidney Int.,21, 492, 1982.
