Thyroid function was explored in 27 CAPD patients and 25 HD patients. Dialysis was associated with low T3 and T4 levels, increased rT3 concentrations, normal T4: T3 and reduced T4: rT3 ratios, normal FT3 and Thyroglobulin concentrations. TSH levels increased during dialysis but still fell within normal limits. The data rule out a condition of primary hypothyroidism and point out to increased thyroidal dismission associated with the block T4-T3 in peripheral cells. Also the increased FT4 levels in CAPD patients could be due to de novo dismission of thyroidal T4.
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ChopraI.J., Chuca TecoG.N., NguyenA.H., SolomonD.H.: In search of an inhibitor of thyroid hormone binding to serum proteins in non-thyroid illnesses.J. Clin. Endocrinol. metab.49: 63, 1979.
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CzernichowP., DauzetM.C., BroyerM., and RappaportR.: Abnormal TSH, PRL, and GH response to TSH releasing factor in chronic uremia.J. Clin. Endocrinol Metabo43: 630, 1976.
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DandonaP., NewronD., ChampionA., and PlattsM.M.: Thyroid function in chronic renal failure.Proc. E.D.T.A.10: 268, 1975.
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FarringtonK., BossA.M.B., VargheseZ., KingstoneD., BaillodR.A., and MoorheadJ.F.: Thyroid function tests in dialyzed patients.Dial Tranplant9: 846, 1980.
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GavinL.A., McMahonF.A., CastleJ.N., CavalieriR.P.: Alterations in serum thyroid hormones and thyroxine binding globulin in patients with nephrosis.J. Clin. Endocrinol. Metab.49: 63, 1970.
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GiordanoC., CarellaC., De SantoN.G., MioliV., BazzatoG., AmatoG., TarchiniA., ColiU., and LandiniS.: Hormonal Status of patients on CAPD and HD.Proc. 1st. International Course on Peritoneal Dialysis. Vicenza 1982. La GrecaG. Ed. Wichtig1982.
13.
KalkW.J., MorleyJ.E., GoldG.H., and MeyersA.: Thyroid function tests in patients on regular hemodialysis.Nephron25: 173, 1980.
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NeuhausK., BaumanG., WalserH., and ThölenH.: Serum thyroxine and thyroxine-binding proteins in chronic renal failure without nephrosis.J. Clin. Endocr. Metab.41: 395, 1975.
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NogimoriT.: A clinical study on thyroid hormone secretion and metabolism in patients with chronic renal failure on hemodialysis.Folia Endocrinol (Japan)57: 903, 1981.
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OddieT.H., FlaniganW.J., FisherD.A.: Iodine and thyroxine metabolism in anephric patients receiving chronic peritoneal dialysis.J. Clin. Endocrinol. Metab.31: 277, 1970.
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PaciniF., PincheraA., GianiC., GrassoL., DoveriF., and BaschieriL.: Serum Thyroglobulin in thyroid carcinoma and other thyroid disorders.J. Endocrino. Invest.3: 283, 1981.
20.
RamirezG., JubitzW., GutchCF., BloomerH.A., SieglerR., and KolffW.J.: Thyroid abnormalities in renal failure.A study of 53 patients on chronic hemodialysis. Ann. Intern. Med.79: 504, 1973.
21.
SavdieE., StewartJ.H., MahonyJ.F., HayerJ.M., LazarusL., SimonsL.A.: Circulating thyroid hormone levels and adequacy of dialysis.Clin. Nephrol.9: 68, 1978.
22.
SilverbergD.S., UlanR.A., FawcettD.M., DossetorJ.B., GraceM., and BettcherK.: Effects of chronic hemodialysis on thyroid function in chronic renal failure.Can. Med. Ass. J.109: 282, 1973.
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SpectorD.A., DavisJ.P., HeldermanJ.H., BellB., and UtigerR.D.: Thyroid function and metabolic state in chronic renal failure.Ann. Intern. Med.85: 724, 1976.
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Van HerleA.J., UllerR.P., MathewsN.L., BrownJ.: Radioimmunoassay for measurement of thyroglobulin in human serum.J. Clin. Invest.52: 1320, 1979: 305
