Plasma activity inducing polymorphonuclear neutrophils (PMN) aggregation, augmenting PMN adherence, plasma chemotatic activity as well as peripheral PMN count were estimated in patients during cardiopulmonary bypass. In the course of the surgical procedure the chemotactic activity and the activity inducing PMN aggregation were detected in plasma. The top of these two activities was always followed by the significant fall of the peripheral PMN count. The increase of the activity augmenting PMN adherence was observed in a part of cases, but when noticed, always preceded the maximum of the remaining evaluated activities.
ChenowethD.E., CooperS.W., HugliT.E., StewartR.W., BlackstoneE.H., KirklinJ.W.: Complement activation during cardiopulmonary bypass.Evidence for generation of C3a and C5a anaphylotoxins. N. Engl. J. Med.304,497, 1981.
CraddockP.R., FehrJ., BrighamK.L., KronenbergR.S., JacobH.S.: Complement and leukocyte-mediated pulmonary dysfunction in hemodialysis.N. Engl. J. Med.296, 769, 1977b.
5.
DamerauB., GrünefeldE., VogtW.: Aggregation of leukocytes induced by the complement-derived peptides C3a and C5a and by three synthetic formylmethionyl peptides.Int. Archs Allergy Appl. Immun.63, 159, 1980.
6.
FehrJ., JacobH.S.: In vitro granulocyte adherence and in vivo margination: two associated complement-dependent functions.Studies based on the acute neutropenia of filtration leukapheresis. J. Exp. Med.146, 641, 1977.
7.
GoldsteinI.M., RoosD., KaplanH.B.: Complement and immunoglobulins stimulate superoxide production by human leukocytes independently of phagocytosis.J. Clin. Invest.56, 1155, 1975.
8.
HammerschmidtD.E., CraddockP.R., McCulloughJ., KronenbergR.S., DalmassoA.P., JacobH.S.: Complement activation and pulmonary leukostasis during nylon fiber leukapheresis.Blood51, 721, 1978.
9.
HammerschmidtD.E., BowersT.K., Lammi-KeefeC.J., JacobH.S., CraddockP.R.: Granulocyte aggregometry: a sensitive technique for the detection of C5a and complement activation.Blood, 55, 898, 1980.
10.
HaslamP.L., TowsendP.J., BranthwaiteM.A.: Complement activation during cardiopulmonary bypass.Anesthesia25, 22, 1980.
11.
JacobH.S., CraddockP.R., HammerschmidtD.E., MoldowC.F.: Complement-induced granulocyte aggregation.An unsuspected mechanism of disease. N. Engl. J. Med.302, 789, 1980.
12.
McGillenJ., PattersonR., PhairJ.P.: Adherence of polymorphonuclear leukocytes to nylon: modulation by prostacyclin (PGI2), corticosteroids, and complement activation.J. Infect. Dis.141, 382, 1980.
13.
MoncadaS., VaneJ.R.: Arachidonic acid metabolites and the interactions between platelets and bloodvessel walls.N. Engl. J. Med.300, 1142, 1979.
RepoH.: Leucocyte migration agarose test for the assessment of human neutrophil chemotaxis.I. Effects of environmental factors on neutrophil migration under agarose. Scand. J. Immunol.6, 203, 1977.
16.
TorenM., GoffinetJ.A., KaplowL.S.: Pulmonary bed sequestration of neutrophils during hemodialysis.Blood36, 337, 1970.
17.
WysockiH., CzarneckiR., Wierusz-WysockaB., BaczykK.: Hemodialysis (HD)-induced granulopenia.Evidence of complement activation role. Proc. of ISAO/IFAC Symp. Warszawa1980a (in press).
