In most insulin-dependent diabetics it is very difficult to achieve and maintain metabolic near-normalisation using conventional insulin injections. It is this deficiency which makes us still uncertain whether diabetic microangiopathy can be prevented, slowed or reversed by strict diabetic control.
MatasA.J., SutherlandD.E., and NajarianJ.S.: Current status of islet and pancreas transplantation ion in diabetes.Diabetes25, 785–795, 1976.
2.
SantiagoJ.V., ClemensA.H., ClarkeW.L., and KipnisD.M.: Closed-loop and open-loop devices for blood glucose control in normal and diabetic subjects.Diabetes28, 71–84, 1979.
3.
SonksenP.H., JuddS.L., and LowyC.: Home monitoring of blood-glucose.Lancet1, 729–732, 1978.
4.
WalfordS., GaleE.A.M., AllisonS.P., and TattersallR.B.: Self-monitoring of blood-glucose.Lancet1, 732–735, 1978.
5.
AlbisserA.M., and LeibelB.S.: The artificial pancreas. Clinics in Endocr.Metab.6, 457–479, 1977.
6.
SlamaG., HautcouvertureM., AssanR., and TchobroutskyG.: One to five days of continuous subcutaneous insulin infusion on seven diabetic patients.Diabetes23, 732–738, 1974.
7.
DeckedT., and LerupB.: Regulation of brittle diabetes by a pre-planned infusion programme.Diabetologia12, 573–579, 1976.
8.
GenuthS., and MartinP.Control of hyperglycaemia in adult Diabetics by pulsed insulin delivery.Diabetes26, 571–581, 1977.
9.
ServiceF. J.: Normalisation of plasma glucose of unstable diabetes: studies under ambulatory, fed conditions with pumped intravenous insulin.J. Lab. Clin. Med.91, 480–489, 1978.
10.
HeppK.D., RennerR., FunckeH.J., MehnertH., HaertenR., and KresseH.: Glucose homeostasis under intravenous insulin therapy in diabetics.Horm. Met. Res. suppl.7, 72–76, 1977.
11.
HannaA.K., MinukH.L., ZinmanB., MarlissE.B., EllmanJ., LeibelB.S., and AlbisserA.M.: A portable system for continuous intravenous insulin delivery: characteristics and results in human diabetics.Clin. Res.26, 630A, 1978.
12.
IrsiglerK., and KritzH.: Long-term continuous intravenous insulin therapy with a portable insulin dosage-regulating apparatus.Diabetes, 28, 196–203, 1979.
13.
PickupJ.C., KeenH., ParsonsJ.A., and AlbertiK.G.M.M.: Continuous subcutaneous insulin infusion: an approach to achieving normoglycaemia.Brit. Med. J.1, 204–207, 1978.
14.
PickupJ.C., KeenH., ParsonsJ.A., and AlbertiK.G.M.M.: Continuous subcutaneous insulin infusion: good blood glucose control for up to 4 days.Diabetologia, 16, 385–389, 1979.
15.
JarretR.J., and KeenH.: Hyperglycaemia and diabetes mellitus.Lancet2, 1009–1012, 1976.
16.
RushforthN.B., MillerM., and BennettP.H.: Fasting and two-hour post-load glucose levels for the diagnosis of diabetes.Diabetologia16, 373–379, 1979.
17.
PickupJ.C., WhiteM.C., KeenH., KohnerE.M., ParsonsJ.A., and AlbertiK.G.M.M.: Long-term continuous subcutaneous insulin infusion in diabetics at home.Lancet, in press, 1979.
18.
PickupJ.C., KeenH., ParsonsJ.A., AlbertiK.G.M.M., and RoweA.S.: Continuous subcutaneous insulin infusion: improved blood glucose and intermediary metabolite control in diabetics.Lancet1, 1255–1258, 1979.
19.
TamborlaneW.V., SherwinR.S., GenelM., and FeligP.: Restoration of normal lipid and amino acid metabolism in diabetic patients with a portable infusion pump.Lancet1, 1258–1261, 1979.
20.
KeenH., and ChlouverakisC.: An immunoassay method for urinary albumin at low concentrations.Lancet2, 913–914, 1963.
21.
VibertiG.C., PickupJ.C., JarrettR.J., and KeenH.: Effect of control of blood glucose on urinary excretion of albumin and β-microglobulin in insulin-dependent diabetes.New Engl. J. Med.300, 638–641, 1979.
22.
WhiteM.C., KohnerE.M., PickupJ.C., and KeenH.: Improvement in retinal vascular changes on continuous subcutaneous insulin infusion (CSII). Presented at British Diabetic Association Meeting, September 1979.
23.
MirouzeJ., SelamJ.L., PhamT.C., MendozaE., and OrsettA.: Sustained insulin-induced remissions of juvenile diabetes by means of an external artificial pancreas.Oiabetologia14, 223–227, 1978.
