This paper reports the effects of initial urea concentrations and pH values on the performance of a capillary hemodialyzer for the removal of free ammonia (NH3) formed by enzymatic hydrolysis of urea. Air was chosen as the gas phase. NaOH was used for alkalinization of dialysate. It was shown that one of the most important parameters was free ammonia concentration. The degrees of alkalinization and the initial urea concentration, were also important. Although even without the addition of NaOH, about 42% of the initial urea can be removed in one hour.
BlaneyT.L., LindanO., SparksR.E.: Adsorption: a step forward toward a wearable artificial kidney.Trans. Am. Soc. Artif. Intern. Organs, 12, 7, 1966.
2.
ChangT.M.S.: Semipermeable aqueous microcapsules (artificial cells): with emphasis on experiments in an extracorporeal shunt system.Trans. Am. Soc. Artif. Intern. Organs, 12, 13, 1966.
3.
ChangT.M.S., MaloufC.: Artificial cells microencapsulated multienzyme system for converting urea and ammonia to amino acid using α-ketoglutarate and glucose as substrate.Trans. Am. Soc. Artif. Intern. Organs, 24, 18, 1978.
4.
CousineauJ., ChangT.M.S.: Formation of amino acid from urea and ammonia by sequential enzyme reaction using a microencapsulated multi-enzyme system.Biochem. Biophys. Res. Commun., 79(1), 24, 1977.
5.
FelsM.: Electrochemical degradation of waste metabolites in dialysate solutions. In: Technical Aspects of Renal Dialysis, FrostT.H. (Ed.), Pitman Medical Publishing Co., Inc., London, England, 226, 1978.
6.
GiordanoC., EspositoR., PluvioM.: Further studies with oxystarch.Kidney Int., 10, 266, 1976.
