Ion-selective electrodes have been used to monitor urea and inorganic phosphate removal during dialysis. The dialysate outflow concentrations from a single pass bedside controller were used to compute instantaneous serum concentrations. The urea data are in agreement with a single pool reservoir model; the inorganic phosphate removal was not log-linear, indicating rate limiting intracompartmental transfer.
The procedure can be applied to the computation of urea generation rates and thus provide information on the protein catabolism rates of the patient; in addition, the monitor provides continuous checks on the dialyzer performance.
KleinE., MontalvoJ.G., WawroR., HollandF.F., and LebeoufA.: Continuous Monitoring of Urea Levels During Hemodialysis. Intl. J. Artif. Organs, 1, no. 3, 116–122(1978).
2.
GotchG.A., SargentJ.A., KeenM., LamM., ProwittM., and GradyM.: Clinical Results of Intermittent Dialysis Therapy Guided by Ongoing Kinetic Analysis of Urea Metabolism. Trans. Amer. Soc. Artif. Int. Organs, 22, 175 (1976).
3.
<Evaluation of Hemodialyzers and Dialysis Membranes>, report of a study group, chaired by Elias Klein, Ph.D., for the Artificial Kidney-Chronic Uremia Program, U.S. Department of Health, Education and Welfare, NIH-NIAMDD, DHEW Publication No. (NIH) 77–1294 (1977).
