This cohort study compared split-thickness skin graft transplantation and dispersed implantation of autologous strip skin (ASS) grafts combined with small autologous columnar skin (SCS) grafts for the treatment of small-area deep burn wounds.
Methods:
The experimental group was treated with dispersed implantation of ASS grafts combined with SCS grafts, whereas the control group underwent split-thickness skin graft (STSG) transplantation.
Results:
The graft survival rate was significantly greater in the experimental group (p < 0.0001). The time to complete epithelialization was similar for both groups (p = 0.6626). The ratio of the donor site area to the wound area was lower (p = 0.0002), and the healing time for the donor site was shorter in the experimental group (p < 0.0001). Additionally, the Vancouver Scar Scale (VSS) scores for both the donor and recipient sites were significantly lower in the experimental group (p < 0.0001, p = 0.0075).
Conclusion:
The combined implantation of ASS and SCS grafts effectively promoted the healing of small-area third-degree burn wounds, with good preservation of hair follicles and sebaceous glands. This method reduces wound contraction and damage to the donor site, with no significant lamellate scar hyperplasia observed during long-term follow-up, making it a viable alternative to split-thickness skin graft transplantation.
OsmanOBHarrisZBZhouJW, et al. In vivo assessment and monitoring of burn wounds using a handheld terahertz hyperspectral scanner. Adv Photonics Res2022; 3(5): 2100095.
2.
SongYTLiuPCZhouXL, et al. Extracellular matrix-based biomaterials in burn wound repair: a promising therapeutic strategy. Int J Biol Macromol2024; 283(Pt 3): 137633.
3.
ChenLYangJWangDY, et al. Multicenter effect analysis of one-step acellular dermis combined with autologous ultra-thin split thickness skin composite transplantation in treating burn and traumatic wounds. Int Wound J2024; 21(1): e14341.
4.
GuFHeWZhuD, et al. A 10-year retrospective study of methicillin-resistant Staphylococcus aureus from burn wound infection in southeast China from 2013 to 2022. Front Microbiol2023; 14: 1301744.
5.
MaruyamaS.Harvesting split-thickness skin from the scalp using a scalpel. Plast Reconstr Surg Glob Open2019; 7(5): e2206.
6.
LindholmVMSalminenAWKoskenmiesSJ, et al. An exploratory randomized clinical trial on negative pressure wound therapy for lower limb full-thickness skin grafts of dermatosurgical patients. Int Wound J2024; 21(6): e14911.
7.
YaoZPengMLiaoJ, et al. Treatment of upper eyelid third-degree burns by dispersed implantation of very small autologous columnar skin grafts: a pilot study of a new method. Burns2022; 48(7): 1671–1679.
8.
HaoXChiYBaiH, et al. Establishment of a Bama miniature pig burn model with different burn depths. Gland Surg2022; 11(10): 1647–1655.
9.
PradhanMPetheP.The molecular mechanisms involved in the hypertrophic scars post-burn injury. Yale J Biol Med2023; 96(4): 549–563.
10.
DasPPalDRoyS, et al. Unveiling advanced strategies for therapeutic stem cell interventions in severe burn injuries: a comprehensive review. Int J Surg2024; 110(10): 6382–6401.
11.
PengMChangDYaoZ, et al. Clinical observation on tiny skin adipose tissue columns in treating granulation wound. Chongqing Med J2022; 51(22): 3840–3846.
12.
YaoZPengMChangD, et al. Autologous small columnar skin dispersedly implanting for treatment of deep back burn: a case report. Chongqing Med J2020; 49(18): 3098–3101.
13.
MaZMoRChenC, et al. Surgical treatment of joint burn scar contracture: a 10-year single-center experience with long-term outcome evaluation. Ann Transl Med2021; 9(4): 303.
14.
YuanBBroadbentJAHuanJ, et al. The effects of adipose stem cell-conditioned media on fibrogenesis of dermal fibroblasts stimulated by transforming growth factor-β1. J Burn Care Res2018; 39(1): 129–140.
15.
KwonSHBarreraJANoishikiC, et al. Current and emerging topical scar mitigation therapies for craniofacial burn wound healing. Front Physiol2020; 11: 916.
16.
ZhuYZhangJHuX, et al. Extracellular vesicles derived from human adipose-derived stem cells promote the exogenous angiogenesis of fat grafts via the let-7/AGO1/VEGF signalling pathway. Sci Rep2020; 10(1): 5313.
17.
YiYHuWZhaoC, et al. Deciphering the emerging roles of adipocytes and adipose-derived stem cells in fat transplantation. Cell Transplant2021; 30: 963689721997799.
18.
KeenanCSCooperLNuutilaK, et al. Full-thickness skin columns: a method to reduce healing time and donor site morbidity in deep partial-thickness burns. Wound Repair Regen2023; 31(5): 586–596.
19.
QinYGeGYangP, et al. An update on adipose-derived stem cells for regenerative medicine: where challenge meets opportunity. Adv Sci (Weinh)2023; 10(20): e2207334.
20.
ZhangMZhangCLiZ, et al. Advances in 3D skin bioprinting for wound healing and disease modeling. Regen Biomater2023; 10: rbac105.
21.
MorokiT.Morphological characteristics and notes of the skin in preclinical toxicity assessment. J Toxicol Pathol2023; 36(2): 85–94.
22.
UrciuoloFCasaleCImparatoG, et al. Bioengineered skin substitutes: the role of extracellular matrix and vascularization in the healing of deep wounds. J Clin Med2019; 8(12): 2083.
23.
ItoYAmagaiM.Controlling skin microbiome as a new bacteriotherapy for inflammatory skin diseases. Inflamm Regen2022; 42(1): 26.
24.
PapaVLi PomiFBorgiaF, et al. Immunosenescence and skin: a state of art of its etiopathogenetic role and crucial watershed for systemic implications. Int J Mol Sci2023; 24(9): 7956.
25.
SmithSCurtisBNicholsonL, et al. Application of a minimally invasive full-thickness autologous microcolumn skin harvesting device for donor site tissue collection and augmenting wound healing in a porcine wound model. Int Wound J2024; 21(12): e70094.
26.
Van KouwenbergEAChiuD. Adipose tissue-preserved skin grafts for lower extremity defects: recommendations to optimize outcomes. Plast Reconstr Surg Glob Open2020; 8(3): e2584.
27.
TamJWangYVuongLN, et al. Reconstitution of full-thickness skin by microcolumn grafting. J Tissue Eng Regen Med2017; 11(10): 2796–2805.
28.
Abu-BakerAȚigăranAEPeligradT, et al. Exploring an innovative approach: integrating negative-pressure wound therapy with silver nanoparticle dressings in skin graft procedures. J Pers Med2024; 14(2): 206.
29.
WangCYuXSuiY, et al. Magnetic resonance imaging data features to evaluate the efficacy of compound skin graft for diabetic foot. Contrast Media Mol Imaging2022; 2022: 5707231.
30.
NiederstätterIMSchieferJLFuchsPC.Surgical strategies to promote cutaneous healing. Med Sci (Basel)2021; 9(2): 45.
31.
RiedlerKHeckerABauerB, et al. The efficacy of regeneration oil and almond oil on split-thickness skin graft donor sites: a single-blinded randomized controlled trial. Clin Pract2023; 13(3): 648–655.
ManekYBJajooSMahakalkarC.A comprehensive review of evaluating donor site morbidity and scar outcomes in skin transfer techniques. Cureus2024; 16(2): e53433.
