This paper describes the clinical experience of a therapy concept involving advanced functions of a new dialysis machine system (5008 Therapy System, Fresenius Medical Care, Bad Homburg Germany) that is able to provide adequate Kt/V for patients, while consuming lower amounts of dialysate, water and energy during the treatment. The novel “AutoFlow” function of this therapy system adjusts automatically the dialysate flow rate according to the effective blood flow rate of the individual patient without compromising the dose of dialysis the patient receives. The new therapy system of Fresenius Medical Care enables a more widespread application of advanced convective treatment modalities in a more affordable manner. (Int J Artif Organs 2007; 30: 577–82)
LedeboI.Convective dialysis therapies: current status and perspective. Ther Apher Dial2005; 9: 223–7.
7.
AhrenholzP., WinklerR.E., RamlowW., TiessM., MullerW.Online hemodiafiltration with pre- and postdilution: a comparison of efficacy. Int J Artif Organs1997; 20: 81–90.
8.
MunozR., GallardoI., ValladaresE., SarachoR., MartinezI., OcharanJ., MontenegroJ.Online hemodiafiltration: 4 years of clinical experience. Hemodial Int2006; 10(suppl 1): S28–32.
9.
MaduellF., del PozoC., GarciaH., SanchezL., Hdez-JarasJ., AlberoM.D., CalvoC., TorregrosaI., NavarroV.Change from conventional haemodiafiltration to on-line haemodiafiltration. Nephrol Dial Transplant1999; 14: 1202–7.
10.
HaukM., KuhlmannM.K., RiegelW., KohlerH.In vivo effects of dialysate flow rate on Kt/V in maintenance hemodialysis patients. Am J Kidney Dis2000; 35: 105–11.
11.
ShinabergerJ.H.Quantitation of dialysis: historical perspective. Semin Dial2001; 14: 238–45.
12.
VanholderR., DeSmetR., LesafferG.Dissociation between dialysis adequacy and Kt/V. Semin Dial2002; 15: 3–7.
13.
GotchF.The basic, quantifiable parameter of dialysis prescription is Kt/V urea; treatment time is determined by the ultrafiltration requirement: all three parameters are of equal importance. Blood Purif2007; 25: 18–26.
14.
KuhlmannU., GoldauR., SamadiN., GrafT., GrossM., OrlandiniG., LangeH.Accuracy and safety of online clearance monitoring based on conductivity variation. Nephrol Dial Transplant2001; 16: 1053–8.
15.
SchneditzD., KaufmanA.M., LevinN.Surveillance of access function by the blood temperature monitor. Semin Dial2003; 16: 483–7.
16.
MaduellF., NavarroV., CruzM.C., TorregrosaE., GarciaD., SimonV., FerreroJ.A.Osteocalcin and myoglobin removal in on-line hemodiafiltration versus low- and high-flux hemodialysis. Am J Kidney Dis2002; 40: 582–9.
17.
MunozR., GallardoI., ValladaresE., SarachoR., MartínezI., OcharanJ., MontenegroJ.Online hemodiafiltration: 4 years of clinical experience. Hemodial Int2006; 10(suppl 1): S28–32.
18.
CanaudB., Bragg-GreshamJ.L., MarshallM.R., DesmeulesS., GillespieB.W., DepnerT., KlassenP., PortF.K.Mortality risk for patients receiving hemodiafiltration versus hemodialysis: European results from the DOPPS. Kidney Int2006; 69: 2087–93.
19.
VaslakiL., KarátsonA., VörösP., MajorL., PethöF., LadányiE., WeberC., MittereggerR., FalkenhagenD.Can sterile and pyrogen-free on-line substitution fluid be routinely delivered? A multicentric study on the microbiological safety of on-line haemodiafiltration. Nephrol Dial Transplant2000; 15(suppl 1): S74–8.
20.
Van LaeckeS., De WildeK., VanholderR.Online haemodiafiltration. Int J Artif Organs2006; 30: 579–85.
21.
CanaudB., MorenaM., Leray-MoraguesH., ChalabiL., CristolJ.P.Overview of clinical studies in hemodiafiltration: what do we need now?Hemodial Int2006; 10(suppl 1): S5–12.
22.
KoomanJ.P., van der SandeF.M., BeerenhoutC.M., LeunissenK.M.On-line filtration therapies: emerging horizons. Blood Purif2006; 24: 159–62.
