Abstract
Aim
The present study explores new signals (capillary 3βhydroxybutyrate - 3 βOHB) for improving the safety of a closed loop insulin infusion system (external wearable artificial pancreas).
Methods
Data collected during a clinical trial on diabetic subjects including a period of insulin deprivation were interpreted through mathematical models to simulate the effect of monitoring ketone bodies (capillary 3βOHB, KB) compared to blood glucose in subjects on Continuous Subcutaneous Insulin Infusion (CSII) treatment.
Results
The estimation of model coefficients satisfactorily fits experimental data. The evaluation of dynamic changes of capillary 3βOHB levels showed a more rapid response than blood glucose.
Conclusions
The effect of the combination of monitoring of glucose and ketone bodies can consistently improve the safety and efficacy of the use of a closed loop system for glycemic control in dangerous situations like ketoacidosis. If a subcutaneous glucose-ketone bodies sensor were to become available in the near future it would be a key component of an external artificial pancreas.
Keywords
Get full access to this article
View all access options for this article.