The etiopathogenesis of sclerosing peritonitis is still debated, with some sustaining that it is a rare form of progression of simple peritoneal sclerosis and others that it is a primitive form. The aim of the present research was to clarify this question.
Material and Methods
438 peritoneal biopsies from 253 patients were re-examined. 174 were obtained prior to peritoneal dialysis and 224 after various periods of dialysis. Forty biopsies were from peritoneal dialysis patients who developed sclerosing peritonitis. Peritoneal morphology was studied for signs of transition from simple sclerosis to sclerosing peritonitis.
Results
Evidence was found sustaining the hypothesis that simple sclerosis to sclerosing peritonitis patients have distinct pathologies.
Conclusions
The results confirm previous observations, excluding the existence of any type of relation between simple peritoneal sclerosis to sclerosing peritonitis.
Di PaoloN., GarosiG.Peritoneal sclerosis. J Nephrol1999; 12: 347–61.
2.
GarosiG., Di PaoloN.Morphological aspects of peritoneal sclerosis. J Nephrol2001; 14(suppl 4): S30–8.
3.
GarosiG., Di PaoloN.Inflammation and gross vascular alterations are characteristic histological features of sclerosing peritonitis. Perit Dial Int2001; 21: 417–8.
4.
Di PaoloN., SacchiG.Atlas of peritoneal histology. Perit Dial Int2000; (suppl 3): S20.
5.
SelgasR., Fernanzed-ReyesM.J., BosqueE., BajoM.A., BorregoF., JimenezC., Del PesoG., De AlvaroF.Functional longevity of the human peritoneum: How long is continuous peritoneal dialysis possible? Results of a prospective medium long-term study. Am J Kidney Dis1994; 23: 64–73.
AfthentopoulosI.E., PassadakisP., OreopoulosD.G., BergmanJ.Sclerosing peritonitis in continuous peritoneal dialysis patients: One center's experience and review of the literature. Adv Ren Replace Ther1998; 5: 157–67.
8.
WilliamsJ.D., CraigK.J., TopleyN., Von RuhlandC., FallonM., NewmanG.R., MacKenzieR.K., WilliamsGT: Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol2002; 13: 470–9.
9.
MateijsenM.A., vanderWalA.C., HendriksP.M., ZweersM.M., MulderJ., StruijkD.G., KredietR.T.Vascular and interstitial changes in the peritoneum of CAPD patients with peritoneal sclerosis. Perit Dial Int1999; 19: 517–25.
10.
YamamotoH., NakayamaM., YamamotoR., OtsukaY., TakahashiH., KatoN., HayakawaH., HasegawaT., IkedaM., YokoyamaK., KawaguchiY., MukaiH., HosoyaT.Fifteen cases of encapsulating peritoneal sclerosis related to peritoneal dialysis: A single centre experience in Japan. Adv Perit Dial2002; 18: 135–8.
11.
NomotoY., KawaguchiY., KuboH.Sclerosing encapsulating peritonitis in patients undergoing continuous peritoneal dialysis. A report of the Japanese Sclerosing Encapsulating Peritonitis Study Group. Am J Kidney Dis1996; 28: 420–7.
12.
DobbieJ.W.Pathogenesis of peritoneal fibrosing syndromes (sclerosing peritonitis) in peritoneal dialysis. Perit Dial Int1992; 12: 14–27.
GarosiG., Di PaoloN.Pathophysiology and morphological clinical correlation in experimental and peritoneal dialysis-induced peritoneal sclerosis. Adv Perit Dial2000; 16: 204–7.
15.
GarosiG., Di PaoloN.Peritoneal sclerosis: One ot two nosological entities?Semin Dial2000; 13: 297–308.
16.
Di PaoloN., SacchiG.Anatomy and physiology of the peritoneal membrane. Contrib Nephrol1990; 84: 10–26.
17.
PlumJ., HermannS., FusshollerA., SchoenickeG., DonnerA., RohrbornA., GrabenseeB.Peritoneal sclerosis in peritoneal dialysis patients related to dialysis settings and peritoneal transport properties. Kidney Int2001; 78(suppl): S42–7.
18.
WilliamsJ.D., CraigK.J., TopleyN., Von RuhlandC., FallonM., NewmanG.R., MacKenzieR.K., WilliamsG.T.Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol2002; 13: 470–9.
19.
RubinJ., HerreraG.A., CollinsD.An autopsy study of the peritoneal cavity from patients on continuous ambulatory peritoneal dialysis. Am J Kidney Dis199118: 97–102.
20.
BertoliS.V., BuziL., CiurlinoD., MaccarioiM., MartinoS.Morpho-functional study of peritoneum in peritoneal dialysis patients. J Nephrol2003; 16: 373–8.
21.
ColesG.A., WilliamsJ.D., TopleyN.Peritoneal inflammation and long-term changes in peritoneal structure and function. In: GokalR., KhannaR., KredietR., NolphK.D., eds. Textbook of Peritoneal Dialysis.Dordrecht: Kluwer Academic Publishers; 2000; 565–83.
22.
Di PaoloN., GarosiG., PetriniG.Morphological and morphometric changes in mesothelial cells during peritoneal dialysis in the rabbit. Nephron1996; 74: 594–9.
23.
DobbieJ.W.Morphology of the peritoneum in CAPD. Blood Purif1989; 7: 74–85.
24.
DobbieJ.W.Peritoneal ultrastructure and changes with continuous ambulatory peritoneal dialysis. Perit Dial Int1993; 13(suppl): S585–7.
GarosiG., Di PaoloN.Peritoneal sclerosis - an overview. Adv Perit Dial1999; 15: 185–92.
27.
RubinJ., GuillermoA., HerreraM.D.An autopsy of the peritoneal cavity from patients on continuous ambulatory peritoneal dialysis. Am J Kidney Dis1991; 17: 97–102.
28.
GotloibL., ShostakA., WajsbrotV.Biocompatibility of dialysis solutions evaluated by histochemical techniques applied to mesothelial cell imprints. Perit Dial Int1993; (suppl 13): S113–5.
WilliamsJ.D., CraigK.J., TopleyN., Von RuhlandC., FallonM., NewmanG.R., MacKenzieR.K., WilliamsG.T.Peritoneal Biopsy Study Group. Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol2002; 13: 470–9.
31.
PlumJ., HermannS., FusshollerA., SchoenickeG., DonnerA., RohrbornA., GrabenseeB.Peritoneal sclerosis in peritoneal dialysis patients related to dialysis settings and peritoneal transport properties. Kidney Int2001; (suppl 78): S42–7.
32.
AfthentopoulosI.E., PassadakiaP., OreopoulosD.Sclerosing peritonitis in continuous ambulatory peritoneal dialysis patients. One centre's experience and review of the literature. Adv Ren Replace Ther1998; 5: 157–67.
33.
NakamotoH., KawaguchiY., SuzukiH.Encapsulating peritoneal sclerosis in patients undergoing continuous ambulatory peritoneal dialysis in Japan. Adv Perit Dial2002; 18: 119–23.
34.
KawanishiH., KawaguchiY., FukuiH.Encapsulating peritoneal sclerosis in Japan; prospective multicenter survey. Am J Kidney Dis2004; 44: 729–37.
35.
SmithL., CollinsJ., MorrisM., TeeleR.Sclerosing encapsulating peritonitis associated with continuous ambulatory peritoneal dialysis: Surgical management. Am J Kidney Dis1997; 29: 456–60.
KortenG., BottcherM., JonasL.Scanning electron microscopy study of the peritoneum as a dialysis membrane a morphological study on the etiology of sclerosing peritonitis. Z Urol Nephrol1988; 81: 473–9.
40.
HendriksP.M., Ho-dac-PannekeetM.M., van GulikT.M.Peritoneal sclerosis in chronic peritoneal dialysis patients: Analysis of clinical presentation, risk factors and peritoneal transport kinetic. Perit Dial Int1997; 17: 136–43.
41.
WirnsbergerG.H., GanserK., DomejW.Sclerosing encapsulating peritonitis: Differential diagnosis to peritoneal encapsulation and abdominal cocoon: A case report. Z Gastroenterol1992; 30: 534–7.
JonesE.A., BronkhorstC.M., de JongeE., ten KateF.J.Sclerosing peritonitis complicated by sepsis: A potential cause of portal hypertension. Eur J Gastroenteral Hepatol1998; 10: 95–8.
45.
SchnebleF., BonzelK.E., WaldherrR.Peritoneal morphology in children treated by continous ambulatory peritoneal dialysis. Pediatr Nephrol1992; 6: 542–6.
46.
MargettsP.J., KolbM., YuL., HoffC.M., HolmesC.J., AnthonyD.C., GauldieJ.Inflammatory cytokines, angiogenesis and fibrosis in the rat peritoneum. Am J Pathol2002; 160: 2285–94.
47.
WilliamsJ.D., CraigK.J., TopleyN.Peritoneal Biopsy Study Group. Morphologic changes in the peritoneal membrane of patients with renal disease. J Am Soc Nephrol2002; 13: 470–9.
