Silicone rubber chambers filled with collagen containing ginsenoside Rb1 (GRb1) were used to repair lesioned rat sciatic nerves with 15-mm gaps between stumps. Six weeks after implantation, histology of the nerve regenerated in the chambers filled with GRb1 and collagen contained larger axons than those in the chambers with collagen only. This study showed that the GRb1 could exert a positive influence on nerve regeneration when using silicone rubber tubes.
KitagawaI., TaniyamaT., ShibuyaH., NodaT., YoshikawaM.Chemical studies on crude drug processing. V. On the constituents of ginseng radix rubra (2): Comparison of the constituents of white ginseng and red ginseng prepared from the same Panax ginseng root (Japanese).Yakugaku Zasshi - J Pharm Soc Jpn1987; 107: 495–505.
2.
TakemotoY., UeyamaT., SaitoH.Potentiation of nerve growth factor-mediated nerve fiber production in organ cultures of chicken embryonic ganglia by ginseng saponins: Structure-activity relationship.Chem Pharm Bull1984; 32: 3128–33.
ChenY.S., HuC.L., HsiehC.L.Effects of percutaneous electrical stimulation on peripheral nerve regeneration using silicone rubber chambers.J Biomed Mater Res2001; 57: 541–9.
5.
SaitoH., SudaK., SchwabM., ThoenenH.Potentiation of the NGF-mediated nerve fiber outgrowth by ginsenoside Rb1 in organ cultures of chicken dorsal root ganglia.Jpn J Pharmacol1977; 27: 445–51.
6.
HimiT., SaitoH., NishiyamaN.Effect of ginseng saponins on the survival of cerebral cortex neurons in cell cultures.Chem Pharm Bull1989; 37: 481–4.
7.
SatouT., NishidaS., HirumaS.A morphological study on the effects of collagen gel matrix on regeneration of severed rat sciatic nerve in silicone tubes.Acta Pathol Jpn1986; 36: 199–208.
8.
DanielsenN., MüllerH., PettmannB.Rat ammion membrane matrix as a substratum for regenerating axons from peripheral and central neurons: Effects in a silicone chamber model.Dev Brain Res1988; 39: 39–50.
9.
GreerR., DanielJ., UemuraE., KudejR., ChenY.S., ChungC.H.Use of a multiple lumen cuff for nerve regeneration.Mat Res Soc Symp Proc1994; 331: 3–11.
10.
UrabeT., ZhaoQ., DanielsenN., LundborgG.Regeneration across a partial defect in rat sciatic nerve encased in a silicone chamber.Scand J Plast Reconstr Surg Hand Surg1996; 30: 7–15.
11.
MadisonR., Da SilvaC.F., DikkesP.Entubulation repair with protein additives increases the maximum nerve gap distance successfully bridged with tubular prostheses.Brain Res1988; 447: 325–34.
12.
WoolleyA.L., HollowellJ.P., RichK.M.Fibronectin-laminin combination enhances peripheral nerve regeneration across long gaps.Otolaryngol Head Neck Surg1990; 103: 509–18.
13.
BaileyS.B., EichlerM.E., VilladiegoA., RichK.M.The influence of fibronectin and laminin during Schwann cell migration and peripheral nerve regeneration through silicon chambers.J Neurocytol1993; 22: 176–84.
14.
DerbyA., EnglemanV.W., FrierdichG.E., NeisesG., RappS.R., RoufaD.G.Nerve growth factor facilitates regeneration across nerve gaps: Morphological and behavioral studies in rat sciatic nerve.Exp Neurol1993; 119: 176–91.
15.
ChenY.S., MillerC., GreerM.H., QuinonesM., GreerR.T.Development of a multiple-lumen nerve cuff utilizing growth stimulant patterns for controlled regeneration.Mat Res Soc Symp Proc1999; 550: 303–12.
16.
KosakaM.Enhancement of rat peripheral nerve regeneration through artery-including silicone tubing.Exp Neurol1990; 107: 69–77.
17.
ChenY.S., HsiehC.L., TsaiC.C.Peripheral nerve regeneration using silicone rubber chambers filled with collagen, laminin and fibronectin.Biomaterials2000; 21: 1541–7.
HollowellJ.P., VilladiegoA., RichK.M.Sciatic nerve regeneration across gaps within silicone chambers: Long-term effects of NGF and consideration of axonal branching.Exp Neurol1990; 110: 45–51.
20.
AebischerP.The role of biomaterials in peripheral nerve regeneration. In: SkalokR., FoxC.F., eds. New York: Alan Liss Inc, 1988. p. 257–62.
21.
LundborgG., DahlinL.B., DanielsenN.P., HanssonH.A., LarssonK.Reorganization and orientation of regeneration nerve fibres, perineurium, and epineurium in performed mesothelial tubes - An experimental study on the sciatic nerve of rats.J Neurosci Res1981; 6: 265–81.
