Adult Stem Cell Technology - Prospects for Cell Based Therapy in Regenerative Medicine

Potten C.S. , Loeffler M. Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. Development 1990; 110: 1001–20.

Thomson J.A. , Itskovitz-Eldor J. , Shapiro S.S. . Embryonic stem cell lines derived from human blastocysts. Science 1998; 282: 1145–7.

Gearhart J. New potential for human embryonic stem cells. Science 1998; 282: 1061.

Shamblott M.J. , Axelman J. , Wang S. . Derivation of pluripotent stem cells from cultured human primordial germ cells. Proc Natl Acad Sci 1998; 95: 13726.

Brustle O. Jones KN, Learish RD, et al. Embryonic stem cell-derived glial precursors: a source of myelinating transplants. Science 1999; 285: 754–6.

Liu S ; Qu Y. , Stewart T.J. . Embryonic stem cells differentiate into oligodendrocytes and myelinate in culture and after spinal cord transplantation. Proc Natl Acad Sci 2000; 97: 6126–31.

Zhang S-C , Wernig M. , Duncan I.D. , Brüstle O. , Thomson J.A. In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Nat Biotechnol 2001; 19: 1129–33.

Reubinoff B.E. , Itsykson P. , Turetsky T. . Neural progenitors from human embryonic stem cells. Nat Biotechnol 2001; 19: 1134–40.

Lumelsky N. , Blondel O. , Laeng P. , Velasco I. , Ravin R. , McKay R. Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets. Science 2001; 292: 1389–94.

Kehat I. , Kenyagin-Karsenti D. , Snir M. . Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes. J Clin Invest 2001; 108: 407–14.

Wakayama T. , Tabar V. , Rodriguez I. , Perry A.C.F. , Studer L. , Mombaerts P. Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer. Science 2001; 292: 740–3.

Saba N. , Abraham R. , Keating A. Overview of autologous stem cell transplantation. Critical Reviews in Oncology/Hematology 2000; 36: 27–48.

Fuchs E. , Segre J.A. Stem cells: A new lease on life. Cell 2000; 100: 143–55.

Slack J.M.W. Stem cells in epithelial tissues. Science 2000; 287: 1431–3.

Kuci S. , Wessels J.T. , Bühring H-J . A novel class of peripheral blood CD34–cells with NOD/SCID repopulating activity. Blood 2000; 96: 281a.

Cotsarelis G. , Sun T.T. , Lavker R.M. Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle and skin carcinogenesis. Cell 1990; 6: 1329–37.

Toma J.G. , Akhavan M. , Fernandes K.J.L. . Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 2001; 3: 778–84.

Epstein E. Jr. . Split stories converge at desmoglein 1. Nat Med 2000; 6: 1213–4.

Huelsken J. , Vogel R. , Erdmann B. , Cotsarelis G. , Birchmeier W. β-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 2001; 105: 533–45.

Jones P.H. , Watt F.M. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 1993; 73: 713–24.

Jones P.H. , Harper S. , Watt F.M. Stem cell patterning and fate in human epidermis. Cell 1995; 80: 83–93.

Lavker R.M. , Sun T-T . Epidermal stem cells: Properties, markers and location. Proc Natl Acad Sci 2000; 97: 13473–5.

Li A. , Simmons P.J. , Kaur P. Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. Proc Natl Acad Sci 1998; 95: 3902–7.

Oshima H. , Rochat A. , Kedzia C. , Kobayashi K. , Barrandon Y. Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell 2001; 104: 233–45.

Tani H. , Morris R.J. , Kaur P. Enrichment for murine keratinocyte stem cells based on cell surface phenotype. Proc Natl Acad Sci 2000; 97: 10960–5.

Taylor G. , Lehrer M.S. , Jensen P.J. , Sun T-T , Lavker R.M. Involvement of follicular stem cells in forming not only the follicle but also the epidermis. Cell 2000; 102: 451–61.

Suzuki A. , Zheng Y-W , Kondo R. . Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver. Hepatology 2000; 32: 1230–39.

Crosby H.A. , Hubscher S. , Fabris L. . Immunolocalization of putative human liver progenitor cells in livers from patients with end-stage primary biliary cirrhosis and sclerosing cholangitis using the monoclonal antibody OV-6. Am J Pathol 1998; 152: 777–9.

Reid L.M. Stem cell/lineage biology and lineage-dependent extracellular matrix chemistry: keys to tissue engineering of quiescent tissues such as liver. In: Lanza R. , Langer R. , Chick W. , ed. Principles of tissue engineering, 1997.

Xu A.S.L. , Luntz T.L. , MacDonald J.M. . Lineage biology and liver. In: Lanza R. , Langer R. , Chick W. , ed. Principles of tissue engineering, 1997.

Sell S. Heterogeneity and plasticity of hepatocyte lineage cells. Hepatology 2001; 33: 738–50.

Alison M. , Sarraf C. Hepatic stem cells. J Hepatol 1998; 29: 676–82.

Sigal S.H. , Brill S. , Fiorino A.S. , Reid L.M. The liver as a stem cell and lineage system. American Physiological Society 1992; G139–48.

Brill S. , Holst P. , Sigal S. . Hepatic progenitor populations in embryonic, neonatal and adult liver. Society for Experimental Biology and Medicine 1993; 261–9.

Strain A.G. , Crosby H.A. Hepatic Stem Cells. Gut 2000; 46: 743–5.

Ramiya V.K. , Maraist M. , Arfors K.E. Schatz DA, Peck AB, Cornelius JG. Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells. Nat Med 2000; 6: 278–82.

Lee J-Y , Qu-Petersen Z. , Cao B. . Clonal isolation of muscle-derived cells capable of enhancing muscle regeneration and bone healing. J Cell Biol 2000; 150: 1085–100.

Gage F.H. Mammalian neural stem cells. Science 2000; 287: 1433.

Bachoud-lévi A.C. , Rémy P. , Ngyuyen J-P . Motor and cognitive improvements in patients with Huntington's disease after neural transplantation. Lancet 2000; 356: 1975–9.

Piccini P. , Brooks D.J. , Bjorklund A. . Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient. Nat Neurosci 1999; 12: 1137–40.

Kondo T. , Raff M. Oligodendrocyte precursor cells reprogrammed to become multipotential CNS stem cells. Science 2000; 289: 1754–7.

Clarke D.L. , Johansson C B. , Wilbertz J. . Generalized potential of adult neural stem cells. Science 2000; 288: 1660–3.

Benedetti S. , Pirola B. , Pollo B. . Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med 2000; 6: 447–50.

Han S.S. , Fischer I. Neural stem cells and gene therapy: prospects for repairing the injured spinal cord. JAMA 2000; 283: 2300–1.

Doetsch F. , Caille I. , Lim D.A. , Garcia Verdugo J.M. , Alvarez Buylla A. Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell 1999; 97: 703–16.

Johansson C.B. , Momma S. , Clarke D.L. , Risling M. , Lendahl U. , Frisen J. Identification of a neural stem cell in the adult mammalian central nervous system. Cell 1999; 96: 25–34.

Rietze R.L. , Valcanis H. , Brooker G.F. , Thomas T. , Voss A.K. , Bartlett P.F. Purification of a pluripotent neural stem cell from the adult mouse brain. Nature 2001; 412: 736–9.

Flax J.D. , Aurora S. , Yang C. . Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes. Nat Biotechnol 1998; 16: 1033–9.

Hering E. Über den Bau der Wirbeltierleber, Sitzber: Akad Wiss Wien, Math Naturic KL 1865; 54: 496–515.

Theise N.D. , Saxena R. , Portmann B.C. . The canals of hering and hepatic stem cells in humans. Hepatology 1999; 30: 1425–33.

Langa F. , Kress C. , Colucci-Guyon E. . Teratocarcinomas induced by embryonic stem (ES) cells lacking vimentin: an approach to study the role of vimentin in tumorigenesis. J Cell Sci 2000; 113: 3463–72.

Bjorklund L.M. , Sanchez-Pernaute R. , Chung S. . Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci USA 2002; 10: 1073.

Thomson J.A. , Itskovitz-Eldor J. , Shapiro S.S. . Embryonic stem cell lines derived from human blastocysts. Science 1998; 282: 1145–7.

Reubinoff B.E. , Pera M.F. , Fong C.Y. , Trounson A. , Bongso A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nat Biotechnol 2000; 18: 399–404.

Cibelli J.B. , Kiessling A.A. , Cunniff K. , Richards C. , Lanza R.P. , West M.D. Somatic cell nuclear transfer in humans: pronuclear and early embryonic development. Journal of Regenerative Medicine 2001; 2: 25–31.

Humpherys D. , Eggan K. , Akutsu H. . Epigenetic instability in ES cells and cloned mice. Science 2001; 293: 95–7.

Beltrami A.P. , Urbanek K. , Kajstura J. . Evidence that human cardiac myocytes divide after myocardial infarction. New Engl J Med 2001; 344: 1750–7.

Lagasse E. , Connors H. , Al-Dhalimy M. . Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000; 6: 1229–34.

Orkin S.H. Stem cell alchemy. Nat Med 2000; 6: 1229–34.

Shen Chia-Ning , Jonathan M. W. Slack, David Tosh. Molecular basis of transdifferentiation of pancreas to liver. Nat Cell Biol 2000; 2: 879–87.

Dabeva M.D. , Hwang S-G , Vasa S.R.G. . Differentiation of pancreatic epithelial progenitor cells into hepatocytes following transplantation into rat liver. Proc Natl Acad Sci USA 1997; 94: 7356–61.

Malouf N.N. , Coleman W.B. , Grisham J.W. . Adult-derived stem cells from the liver become myocytes in the heart in vivo. Am J Pathol 2001; 158: 1929–35.

Pearson H. Liposuction may harvest stem cells. Nature Science Update, 11 April 2001 (overview, cites Zuk PA, et al. Multilineage cells from human adipose tissue: implications for cell-based therapys. Tissue Engineering 2001; 7, 211–28).

Bjornson C.R.R. , Rietze R.L. , Reynolds B.A. , Magli M.C. , Vescovi A.L. Turning brain into blood: A hematopoietic fate adopted by adult neural stem cells in vivo. Science 1999; 283: 534–7.

Galli R. , Borello U. , Gritti A. . Skeletal myogenic potential of human and mouse neural stem cells. Nat Neurosci 2000; 3: 986–91.

Jackson K.A. , Mi T. , Goodell M.A. Hematopoietic potential of stem cells isolated from murine skeletal muscle. Proc Natl Acad Sci 1999; 96: 14482–6.

Toma J.G. , Akhavan M. , Fernandes K.J.L. , Barnabé-Heider F. , Sadikot A. , Kaplan D.R. , Miller F.D. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 2001; 3: 778–84.

Pearson H. True stem cell found? Nature Science Update, May 4 2001 (overview, cites Krause D.S. , Theise N.D. , Collector M.I. , Henegariu O. , Hwang S. , Gardener R. , Neutzel S. , Sharkis S.J. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105: 369–77).

Krause D.S. , Theise N.D. , Collector M.I. . Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105: 369–77.

Davern T.J. Bloody Liver - Prometheus revised (comment). Hepatology 2001; 34: 212–4.

Mitaka T. Hepatic stem cells: From bone marrow cells to hepatocytes. Biochem Biophys Res Commun 2001; 281: 1–5 (overview).

Petersen B.E. , Bowen W.C. , Patrene K.D. . Bone marrow as a potential source of hepatic oval cells. Science 1999; 284: 1168–70.

Theise N.D. , Badve S. , Saxena R. . Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology 2000; 31: 235–40.

Theise N.D. , Nimmakayalu M. , Gardener R. . Liver from bone marrow in humans. Hepatology 2000; 32: 11–6.

Lagasse E. , Connors H. , Al-Dhalimy M. . Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med 2000; 6: 1229–34.

Alison M.R. , Poulsom R. , Jeffery R. . Hepatocytes from non-hepatic adult stem cells. Nature 2000; 406: 257.

Brazelton T.R. , Rossi F.M. , Keshet G.I. , Blau H.M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 2000; 290: 1775–9.

Mezey É , Chandross K.J. , Harta G. , Maki R.A. , McKercher S.R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000; 290: 1779–82.

Krause D.S. , Theise N.D. , Collector M.I. . Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001; 105: 369–77.

Shimizu K. , Sugiyama S. , Aikawa M. . Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy. Nat Med 2001; 7: 738–41.

Kaushal S. , Amiel G.E. , Guleserian K.J. . Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo. Nat Med 2001; 7: 1035–40.

Gao Z-H , McAlister V.C. , Williams M. Repopulation of liver endothelium by bone-marrow-derived cells. Lancet 2001; 357: 932–3.

Pearson H. Hope stems for broken hearts. Nature Science Update, 31 March 2001.

Orlic D. , Kajstura J. , Chimenti S. . Transplanted hematopoietic stem cells repair myocardial infarcts. Blood 2000; 96: 221a.

Orlic D. , Kajstura J. , Chimenti S. . Bone marrow cells regenerate infarcted myocardium. Nature 2001, 410: 701–5.

Quaini F. , Urbanek K. , Beltrami A.P. . Chimerism of the transplanted heart. New Engl J Med 2002; 346: 5–15.

Kocher A.A. , Schuster M.D. , Szabolcs M.J. . Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med 2001; 7: 430–6.

Lyden D. , Hattori K. , Dias S. . Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth. Nat Med 2001; 7: 1194–201.

Priller J. , Flugel A. , Wehner T. . Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment. Nat Med 2001; 7: 1356–61.

Bulte J.W.M. , Douglas T. , Witwer B. . Magnetodendrimers allow endosomal magnetic labeling and in vivo tracking of stem cells. Nat Biotechnol 2001; 19: 1141–7.

Orlic D. , Kajstura J. , Chimenti S. . Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc Natl Acad Sci 2001; 98: 10344–9.

Palmer T.D. , Schwartz P.H. , Taupin P. , Kaspar B. , Stein S.A. , Gage F.H. Cell culture: Progenitor cells from human brain after death. Nature 2001; 411: 42–3.

Gluckman E. Hematopoietic stem-cell transplants using umbilical-cord blood. New Engl J Med 2001; 344: 1860–1.

Gerlach J. , Schnoy N. , Encke J. , Müller C. , Smith M. , Neuhaus P. Improved hepatocyte in vitro maintenance in a culture model with woven multicompartment capillary systems: electron microscopy studies. Hepatology 1995; 22: 546–52.

Gerlach J. Development of a hybrid liver support system - a review. Int J Artif Organs 1996; 19: 645–55.

Mizuguchi T. , Hui T. , Palm K.S. . Enhanced proliferation and differentiation of rat hepatocytes cultured with bone marrow stromal cells. J Cell Physiol 2001; 189: 106–19.

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Mahoney M.J. , Saltzman W.M. Transplantation of brain cells assembled around a programmable synthetic microenvironment. Nat Biotechnol 2001; 19: 934–9.