Will Regenerative Medicine Live Up to Its Name?

Abstract

Keywords

regenerative medicine mesenchymal stromal cells gene therapy exosomes induced pluripotent stem cells

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References

Amor

Feucht

Leibold

, et al. Senolytic CAR T cells reverse senescence-associated pathologies. Nature. 2020;583(7814):127-132.

Barrett

Cannon

Forte

Hunt

Jang

Smith

International call for a 10-year moratorium on heritable human genome editing: a multi-stakeholder initiative to ensure safe and responsible use of genetic technologies. Cytotherapy. Published online May 22, 2025. doi:10.1016/j.jcyt.2025.05.007

Blanc

Dazzi

English

, et al. ISCT MSC committee statement on the US FDA approval of allogenic bone-marrow mesenchymal stromal cells. Cytotherapy. 2025;27(4):413-416.

Caplan

AI.

Mesenchymal stem cells. J Orthop Res. 1991;9(5):641-650.

E-CEL UVEC cells as an adjunct cell therapy for the arthroscopic rotator cuff repair in adults. NCT04057833. ClinicalTrials.gov. Available at: https://clinicaltrials.gov/study/NCT04057833?cond=NCT04057833&rank=1. Accessed June 1, 2025.

FDA approves remestemcel-L-rknd for steroid-refractory acute graft versus host disease in pediatric patients. US Food and Drug Administration. Available at: https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-remestemcel-l-rknd-steroid-refractory-acute-graft-versus-host-disease-pediatric. Accessed June 1, 2025.

Florida Senate Bill 1768. CS/CS/SB 1768: Stem Cell Therapy. Available at: https://www.flsenate.gov/Session/Bill/2025/1768. Accessed June 1, 2025.

Friedenstein

Piatetzky-Shapiro

Petrakova

KV.

Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol. 1966;16(3):381-390.

Kim

, et al. A multicenter, double-blind, phase III clinical trial to evaluate the efficacy and safety of a cell and gene therapy in knee osteoarthritis patients. Hum Gene Ther Clin Dev. 2018;29(1):48-59.

10.

Kyoto University generates high-quality cartilage made from iPS-derived iMSCs. Science Japan. July 24, 2023. Available at: https://sj.jst.go.jp/news/202307/n0724-01k.html. Accessed June 1, 2025.

11.

Müller

Taubmann

Bucci

, et al. CD19 CAR T-cell therapy in autoimmune disease: a case series with follow-up. N Engl J Med. 2024;390(8):687-700.

12.

Ohno

Nakamura

Advancing autoimmune rheumatic disease treatment: CAR-T cell therapies. Evidence, safety, and future directions. Semin Arthritis Rheum. 2024;67:152479.

13.

Park

Seo

Lee

, et al. TissueGene-C induces long-term analgesic effects through regulation of pain mediators and neuronal sensitization in a rat monoiodoacetate-induced model of osteoarthritis pain. Osteoarthritis Cartilage. 2023;31(12):1567-1580.

14.

Phase 1b clinical trial to evaluate PEP and EUFLEXXA for knee osteoarthritis (KOA). NCT06463132. ClinicalTrials.gov. Available at: https://clinicaltrials.gov/study/NCT06463132?cond=NCT06463132&rank=1. Accessed June 1, 2025.

15.

Sawamoto

Doi

Nakanishi

, et al. Phase I/II trial of iPS-cell-derived dopaminergic cells for Parkinson’s disease. Nature. 2025;641(8064):971-977.

16.

A study of NCR100 injection for the treatment of knee osteoarthritis (KOA). NCT06741098. ClinicalTrials.gov. Available at: https://clinicaltrials.gov/study/NCT06741098?cond=NCT06741098&rank=1. Accessed June 1, 2025.

17.

Takahashi

Yamanaka

Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126(4):663-676.

18.

Wong

Teo

KYW

Law

, et al. Mesenchymal stem cell exosome and fibrin sealant composite enhances rabbit anterior cruciate ligament repair. Am J Sports Med. 2025;53(4):871-884.

19.

Zhang

Wong

Ren

, et al. Mesenchymal stem cell exosomes promote functional osteochondral repair in a clinically relevant porcine model. Am J Sports Med. 2022;50(3):788-800.

20.

Zhang

Han

, et al. 3-dimensional bioprinting of a tendon stem cell-derived exosomes loaded scaffold to bridge the unrepairable massive rotator cuff tear. Am J Sports Med. 2024;52(9):2358-2371.