Abstract
Purpose:
In order to study the degree of reliability of the cancer positive response in the Colon found by Bi-Digital O-Ring Test (OMURA, Y., 1977-2000; BDORT) originally found and developed by Prof. Omura, Y. in New York, cancer positive tissues by Bi-Digital O-Ring Test were evaluated with standard pathological examination.
Subjects:
432 Patients (197 Males, 235 Females, ranging from 21-84 years old who visited Shimotsuura Hospital Out-Patient Clinic, Kurume, Japan for a general check-up for a period of about 28 months after September, 1997) who were found to have cancer positive response by BDORT in the colon. On these patients, a total of 865 O-Ring Test cancer positive areas were made.
Methods:
Cancer screening was made using Omura’s method of detecting pre-cancer or cancer (discovered in 1988-1989), which looks for the co-existence of a strong positive for Oncogene C-fos Ab2, Integrin α5β1,Mercury & virus and disappearance (marked reduction) of acethylcholine. The exact location of the positive areas were mapped on the body surface. Subsequently, standard laboratory tests were performed on these patients with Optic fiber evaluation of the colon, and microscopic evaluation of pathological tissues.
Results:
1) Among the patients who were found the cancer positive response in the colon with positive response of Oncogene C-fos Ab2, etc. by BDORT, 865 locations were checked with Optic fiber evaluation of the colon, and microscopic evaluation of pathological tissues. Patho- histological examination results were as follows: a) Group 1 (Hyperplastic polyp): 480 Iocations(55.5%) b) Group2:48 locations(5.5%) c) Group3(Tubular adenoma with moderate state): 321 locations(37.1%) d) Group 4 (Tubular adenoma with severe state): 16 locations (1.8%) e) Colon cancer (Adenocarcinoma of colon:3, carcinoid tumor:1) :4 locations (0.5% of all the O-Ring positive areas).
2) Case results of total 432 cases were as follows: a) Group 1 (Hyperplastic polyp): 220 cases (50.9%) b) Group2:48 cases (11.1%) c) Group3 (Tubular adenoma with moderate state): 177 cases (41.0%) d) Group 4 (Tubular adenoma with severe state): 11 cases (2.5%) e) Colon cancer (Adenocarcinoma of colon:3, carcinoid tumor: 1) :4 cases (0.93% of all the O-Ring positive patients). Cancer detection rate among the positive reaction in the colon with BDORT examination was 0.93%. If we include Group 3 (Tubular adenoma with moderate state) and Group 4(Tubular adenoma with severe state) that are pre-cancer stages, the detection rate of pre-cancer or cancer in colon by BDORT examination was 44.4%(192/432).
Discussion:
In O-Ring Test cancer positive areas, protruding pathological changes were discovered in high frequencies, but the detection rate of the actual cancer itself was of a small percentage (less than 1% of patients came for general check-ups). However, if polyp due to adenoma is considered as a pre-cancer state, detection rate of pre-cancer was 44.4%. According to the present medical diagnostic standard, some of the pathological changes are classified as hyperplastic polyps or inflammatory polyps; but the Bi-Digital O-Ring Test also indicates an identical response to pre-cancer or cancer. This suggests that some of the tissues presently considered to be benign and have nothing to do with pre-cancer or cancer may in reality be precancer itself. This study indicated that the Bi-Digital O-Ring Test is very useful, powerful diagnostic tool for the screening of cancer and pre-cancer tissue and so every physician should take advantage of it, since there are no better simple, safe, and economical methods which have as high a detection rate as the Bi-Digital O-Ring Test cancer screening method. Besides we need further study and investigation of the sensitivity, specificity, accuracy of each cancer parameter of BDORT and their combination assay.
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