Diagnostic Rate of the Cancer by BDORT Utilizing the Cancer Slide

Abstract

Purpose:

To make a diagnosis of cancer with BDORT (resonance test), we can choose two methods. One is to use a chemical agent like Integrin α5β1 or Oncogene C-fos Ab2, the other is to use microscopic cancer slides. These two methods were originally introduced by Prof. Omura of New York. The former is sensitive but not specific and the latter is not so sensitive but is specific. It is useful to investigate the diagnostic sensitivity of the microscopic cancer slide and the specificity of it to the type and differentiation of the cancer in order to utilize them to detect the presence of cancer tissue in clinical medicine.

Methods and Materials:

78 patients, made diagnosis of cancer, (gastric cancer: 30, colon cancer: 22, hepatocellular carcinoma (HCC): 5, Gall Bladder carcinoma: 1, Cholangiocarcinoma: 2, Pancreas carcinoma: 7, Breast cancer: 11) were analyzed. The cancer slides used were as follows.

Table 1

Used slides to detect the Cancer

Disease	Cancer slide
Gastric cancer	Tubular adenoca. / Poorly diff. Adenoca. / Signet-ring cell ca.
Colon cancer	Well diff. Adenoca./ Mucinous ca.
Hepatocellularr cancer	Moderately diff. adenoca.
GB & Cholangiocarcinoma	Well diff. adenoca.
Pancreas cancer	Tubular adenoca.
Breast cancer	Papillolubular ca. (A)(B)/ Solid-tubular ca./ Schirrous ca.
All malignant disease	Malignant lymphoma B-cell type of Colon

Result:

Diagnostic rates were as follows.

Table 2

Diagnostic rate of the Cancer by corresponding cancer slides

Disease	Diagnostic rate of each slide
Gastric cancer	Tubular adeno ca.	Poorly diff. Adeno ca.	Signet-ring cell ca.
	66.7%	66.7%	66.7%
Colon cancer	Well diff. Adeno ca.	Mucinous ca.
	95.7%	4.3%
Hepatocellar carcinoma	Moderately diff. adenoca.
	100.0%
GB & Cholangiocarcinoma	Well diff. adenoca.
	100.0%
Pancreas cancer	Tubular adenoca.
	100.0%
Breast cancer	Papillotubular ca. (A)	Papillotubular ca. (B)	Solid-tubular ca.	Schirrous ca.
	45.5%	72.7%	54.5%	63.6%

Table 3

No. of cancer resonance test positive slides

	No response	1 slide	2 slides	3 slides	4 slides
Gastric Ca.	0(0.0%)	8(26.7%)	14(46.7%)	8(26.7%)
Colorectal Ca.	0(0.0%)	22(95.7%)	14.3(4.3%)
Hepatocellar carcinoma	0(0.0%)	5(100%)
GB&BD Ca.	0(0.0%)	3(100%)
Pancreas Ca.	0(0 0%)	3(100%)
Breast Ca.	0(0.0%)	4(36.4%)	2(18 2%)	3(27.3%)	2(18.2%)

To make diagnosis of cancer completely (100%), gastric cancer needed 3 slides, colon cancer did 2 slides, Hepatoceller, GB & Cholangiocarcinoma, and Pancreas cancer did only 1 slide, and breast cancer did 4 slides.

Table 4

Diagnostic rate of the Cancer by B-cell Malignant lymphoma slide

Disease	No. of Pt.	Rate (%)
Gastric cancer	30	100
Colon cancer	22	93.4
Hepatocellular cancer	5	100
GB & Cholangiocarcinoma	1/2	100
Pancreas cancer	7	100
Breast cancer	11	100

Discussion:

There was no correlation between the cancer tissue type, differentiation and tissue type of microscopic cancer slides. To make diagnosis of the cancer with the microscopic slides, several samples should be added by repeating the examination with trial and error, because of the specificity of resonance cannot be obvious. Diagnostic rate of the Cancer by B-cell Malignant lymphoma slide is very high but isn’t reach 100%. It is useful to screen cancer, because the response has less effect of tissue volume or concentration, different from chemical agent like Integrin α5β1 or Oncogene C-fos Ab2. Further examination is needed to make diagnostic rate to 100%, utilizing T-cell Malignant lymphoma slide or others.