Abstract
Electro-magnetic fields can dilate the diameter of vessels in pathological lesions and increase the drug translation into the lesions. The drug translation may depend on the strength of electromagnetic fields. We tried to determine what grade of electro-magnetic field is effective to dilate the vessels in pathological lesions.
Yoshida sarcoma cells were implanted intradermally to the abdominal wall of male Donryu rats, and on the 7th implanted day, when the tumor size was about 20mm in diameter, 24Donryu rats were assigned to four groups by the grades of electromagnetic fields, 5mG to group A, 10mG to group B, 15mG to group C, 0mG to control. Each grade of electro-magnetic field was supplied by 2.0 cm in diameter of round coil with direct current of six volts. Then it was applied around the tumor for 60 minutes before the injection of Img/kg of Doxorubicin through the tail vein, and 15 minutes later the tumor and the normal abdominal wall were removed for Doxorubicin assay.
The Doxorubicin concentrations of tumor compared to those of normal abdominal wail were 156% in group A, 152% in group B, 123% in group C. It means that the application of 5mG and 10mG of electro-magnetic fields were significantly effective to the translation of the drug than 15mG of it.
In the conclusion, the effect of electro-magnetic fields depends on the grade of electromagnetic field applied.
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