There is evidence that some antidepressant drugs, above all amitriptyline and mianserine, are beneficial in the prophylaxis of migraine. The mechanism of action of antidepressants in migraine is likely to be complex. Mood disturbances accompanying migraine syndromes suggest a mode of action of such a class of drugs. In the last few years some clinical studies tend to show that the antimigraine effects of these drugs seem relatively independent of the antidepressant activity.
CouchJRZieglerDKHassaneinRS. Amitriptyline in the prophylaxis of migraine. Neurology1976;26:121–7.
2.
MonroPSwadeCCoppenA. Double blind comparative study of mianserin vs placebo in the prophylaxis of migraine. Clin Neuropharmacol (suppl)1984;7:654–5.
3.
MartucciNAgnoliAMannaVBocolaV. Headache and noradrenergic involvement: study with alpha-2 stimulants and blockers. Clin Neuropharmacol (suppl)1984;7:656–7.
4.
CouchJRHassaneinRS. Amitriptyline in migraine prophylaxis. Arch Neurol1979;36:695–9.
5.
EdvissonLOwanC. Pharmacological characterization of postsynaptic vasomotor receptors in brain vessels. In: OwanCEdvissonL eds Neurogenic control of the brain circulation, New York: Pergamon Press, 1977:169–83.
6.
AgnoliADenaroACeciEFalaschiA. On the etiopathogenesis of migraine: a possible link between the amine and endorphine hypothesis. In: Advances in neurology, vol 33, New York: Raven Press, 1982:99–106.
7.
GilmanAGGoodmanLSGilmonA. Goodman and Gilman's the Pharmacological basis of therapeutics. 6th ed.New York: Macmillan Publishing Co., 1980:609–46.
8.
DalkvistJEkbomKWaldenlindE. Headache and mood: a time-series analysis of self-ratingsCephalalgia, 1984;4:45–52.
9.
KudrowLOSuktusBJ. MMPI pattern specificity in primary headache disorders. Headache1979;19:18–24.
10.
SternbachRADalessioDJKunzelMBowmanGE. MMPI patterns in common headache disorders. Headache1980;19:311–6.
11.
MerskeyH. Pain and emotion: their correlation in headache. In: Neurology, vol 33. New York: Raven Press, 1982;135–43.
12.
De DominiPDel BeneESavelliniS GoriManzoniGCMartucciNNappiGSavoldiF. Personality patterns of headache sufferers. Cephalalgia (suppl)1983;3:195–214.
13.
MoskowitzASLiebeskindJC. Neural and neurochemical substrates of pain and pain inhibition. Sem Neurol1983;3:323–30.
14.
WardNGBloomVLFriedelRO. The effectiveness of tricyclic antidepressants in the treatment of coexisting pain and depression. Pain1979;7:331–41.
15.
BotneyMFieldsJL. Amitryptiline potentiates morphine analgesia by a direct action on the central nervous system. Ann Neurol1983;13:160–4.
