Seventy-five consecutive patients referred to an anaesthetic allergy clinic were intradermally tested with atracurium and cisatracurium. With the exception of one patient the results were identical, suggesting that allergy to either drug is associated with allergy to the stereoisomer. For skin testing for allergy to neuromuscular blocking drugs it is only necessary to use either atracurium or cisatracurium and cisatracurium is the preferred drug.
LaveryG.G., ClarkeR.S.J., WatkinsJ.Histaminoid response after intradermal and intravenous administration of atracurium, vecuronium and d-tubocurarine: a comparison. Eur J Anaesthesiol1986; 3: 439–444.
2.
NorthF.C., KettlehampN., HirshmanC.Comparison of cutaneous and in vitro histamine release by muscle relaxants. Anesthesiology1987; 66: 543–546.
3.
DoenickeA., SoukupJ., HoerneckeR., MossJ.The lack of histamine release with cisatracurium: A double blind comparison with vecuronium. Anesth Analg1997; 84: 623–628.
4.
BaldoB.A., FisherM.M.Substituted ammonium ions as allergenic determinants in drug allergy. Nature1983; 706: 262–264.
5.
FisherMMcD, BoweyC.J.Intradermal compared with prick testing in the diagnosis of anaesthetic allergy. Br J Anaesth1997; 79: 59–63.
