Abstract

References
1.
Hill
A.V.
The possible effect of the aggregation of molecules of haemoglobin on its dissociation curves. J Physiol (Lond) 1910 ; 40 : (Proc) iv –vii .
2.
Hull
C.J.
Pharmacokinetics for anaesthesia. Butterworth-Heinemann , Oxford , 1991 ; 216 –223 .
3.
Sheiner
L.B.
,
Stanski
D.R.
,
Vozeh
S.
,
Miller
R.D.
,
Ham
J.
Simultaneous modelling of pharmacokinetics and pharmacodynamics: Application to d-tubocurarine. Clin Pharmacol Ther 1979 ; 25 : 360 –371 .
4.
Dreyer
F.
Acetylcholine receptor. Br J Anaesth 1982 ; 54 : 115 –130 .
5.
Hull
C.J.
Pharmacokinetics for anaesthesia. Butterworth-Heinemann , Oxford 1991 ; 220 .
6.
Torda
T.A.
,
Graham
G.G.
,
Love
B.L.
A clinician looks at the pharmacokinetics and pharmacodynamics of neuromuscular blocking drugs. In:
Rand
M.J.
,
Raper
C.
, eds. Pharmacology. Elsevier , Amsterdam 1987 ; 99 –102 .
7.
Shackell
L.F.
,
Williamson
W.
,
Deitchmann
L.L.
,
Katzman
B.S.
The relation of dosage to effect. J Pharmacol 1924 ; 25 : 53 –61 .
8.
Torda
T.A.
,
Graham
G.G.
,
Tsui
D.
Neuromuscular sensitivity to atracurium in humans. Anaesth Intens Care 1990 ; 18 : 62 –68 .
9.
Hull
C.J.
,
Van Beehm
H.B.H.
,
McLeod
K.
,
Sibbald
A.
,
Watson
M.J.
A pharmacokinetic model for pancuronium. Br J Anaesth 1978 ; 50 : 1113 –1121 .
10.
Hull
C.J.
,
English
M.J.M.
,
Sibbald
A.
Fazadinium and pancuronium: A pharmacodynamic study. Br J Anaesth 1980 ; 52 : 1209 –1221 .
11.
Schwartz
G.
Estimating the dimension of a model. Ann Stat 1978 ; 6 : 461 –464 .
12.
Holford
N.H.G.
,
Sheiner
L.B.
Pharmacokinetic and pharmacodynamic modelling in vivo. CRC Critical Reviews in Bioengineering 1981 ; 5 : 273 –322 .
