A retrospective study in coronary artery bypass graft patients was undertaken to assess the effect of gentamicin and a bypass prime with a high calcium on the incidence of renal failure. Patients who received both Haemaccel (polygeline, Hoechst Marion Roussel) (calcium concentration 6.25 mmol/l) in the bypass prime and gentamicin perioperatively had a higher incidence of renal failure compared with those who received only Haemaccel (P=0.005), only gentamicin (P=0.002) or neither (P=0.0001). We suggest that the combination be avoided in this group of patients.
LangeHW, AeppliDM, BrownDC.Survival of patients with acute renal failure requiring dialysis after open heart surgery: Early prognostic indicators. Am Heart J1987; 113:1138–1143.
4.
ParfreyPS, GriffithsSM, BarretBJ, et al. Contrast material-induced renal failure in patients with diabetes mellitus, renal insufficiency, or both. A prospective controlled study. N Engl J Med1989; 320:143–149.
5.
RockRC, WalkerWG, JenningsCD.Nitrogen metabolites and renal function. In: Textbook of Clinical Chemistry.TietzNW, ed. Publisher 1986, ch. 11; p 1276.
6.
OhriSK, AbelPD.The pathophysiology of nephrourological complications following cardiopulmonary bypass. Perfusion1991; 6:79–91.
7.
LuftFC, YumMN, WalkerPO, et al. Gentamicin gradient patterns and morphological changes in human kidneys. Nephron1977; 18:167.
8.
WalkerPD, ShahSV.Evidence suggesting a role for hydroxyl radical in gentamicin-induced acute renal failure in rats. J Clin Invest1988; 81:334–341.
9.
ZagerRA.Gentamicin effects on renal ischaemia/reperfusion injury. Circ Res1992; 70:20–28.
10.
HyneckML, BerardiRR, JohnsonRM.Interference of cephalosporins and cefoxitin with serum creatinine determination. Am J Hosp Pharm1981; 38:1348–1352.
11.
HumesDH.Role of calcium in pathogenesis of acute renal failure. Am Phys Soc1986; F579–F589.
12.
WeinbergJM.The role of cell calcium overload in nephrotoxic renal tubular cell injury. Am J Kid Dis1986; 8:284–291.
13.
SkellyAM, JohnsonALM, WhitWAM.Changes in ionised plasma calcium levels during cardiopulmonary bypass with different pump primes. J Cardiothorac Vasc Anesth1994; 8(Supp 3):36.
14.
CohenR, JohnsonK, HumesHD.Potentiation of aminoglycoside nephrotoxicity by vitamin-D-induced hypercalcaemia. Min Electrol Metals1988; 14:121–128.
15.
ElliottWC, PatchinDS, JonesDB.Effect of parathyroid hormone activity on gentamicin nephrotoxicity. J Lab Clin Med1987; 109:48–54.
16.
ValentineS, BarrowcliffeM, PeacockJ.A comparison of the effects of fixed and tailored cardiopulmonary bypass flowrates on renal function. Anaesth Intensive Care1993; 21:304–308.
17.
CramerBC, ParfreyPS, HutchinsonTA, et al. Renal function following infusion of radiological contrast material: a prospective controlled study. Arch Intern Med1985; 145:87–89.
