The effect of low dose (50 KIU/ml) and high dose (200 KIU/ml) aprotinin on standard thrombelastographic variables (r, K, α, MA) was examined in vitro using blood from forty ASA Class I patients. Both concentrations of aprotinin resulted in minor increases in r time above the normal range (P<0.05). Aprotinin did not alter other thrombelastographic variables. The results indicate that aprotinin is a mild direct anticoagulant in vitro as assessed by thrombelastography.
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Product information.Overview of the thrombelastograph coagulation analyzer. Haemoscope Corporation, Skokie, IL, USA.
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