Pain is a well known complication of propofol injection. Premixing with lignocaine 0.1 mg.kg−1 and injection into a large forearm vein has been recommended. The amount of lignocaine to be added is often empirical when the vein on the dorsum of the hand is used. In this study we attempt to determine the optimal amount of lignocaine necessary to reduce pain when propofol is injected into a hand vein. Our study shows that a propofol emulsion containing 0.05% lignocaine is effective in reducing the incidence of propofol injection pain. The addition of lignocaine also reduces the incidence of excitatory effects. Increasing the dosage of lignocaine above 0.05% does not improve the results.
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2.
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11.
MajorE., VerniquetA.J.W., WaddelT.K., SavegeT.M., HofflerD.E., AvelingW.A study of three doses of ICI 35868 for induction and maintenance of anaesthesia. Br J Anaesth1981; 53: 267–272.
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KlementW., ArndtJ.O.Pain on I.V. injection of some anaesthetic agents is evoked by the unphysiological osmolality or pH of their formulations. Br J Anaesth1991; 66: 189–195.
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KawarP., DundeeJ.W.Frequency of pain injection and venous sequelae following the I.V. administration of certain anaesthetics and sedatives. Br J Anaesth1982; 54: 935.
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ValtonenM., IisaloE., KantoJ., RosenbergP.Propofol as an induction agent in children: pain on injection and pharmacokinetics. Acta Anaesth Scand1988; 32: 502–504.
16.
MillarJ.M., BarrA.M.The prevention of pain on injection. A study of the effect of intravenous lignocaine before methohexitone. Anaesthesia1981; 36: 878–880.
17.
BrownP.M., MossE.Reduction of pain on injection of etomidate. Anaesthesia1981; 36: 814–816.
18.
LimE.T.M., KhooS.T., TweedW.A.Efficacy of lignocaine in alleviating potassium chloride infusion pain. Anaesth Intens Care1992; 20: 196–198.
19.
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20.
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