Four patients with genetic cholinesterase abnormalities were studied with electromyography after being given suxamethonium 0.1 mg/kg. An abnormal homozygous patient was paralysed for 17 minutes. The duration of response in heterozygous patients was 2–4 minutes, being shorter when cholinesterase activity levels were near normal.
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4.
SmithC., LewisG., DonatiF., BevanD.R.Dose-response relationship for succinylcholine in a patient with genetically determined low plasma cholinesterase activity. Anesthesiology1989; 70: 156–158.
5.
CheralaS.R., EddieD.N., SechzerP.H.Placental transfer of succinylcholine causing transient respiratory depression in the newborn. Anaesth Intens Care1989; 17: 202–204.
6.
Viby MogensenJ., HanelH.K.Prolonged apnoea after suxamethonium. An analysis of the first 225 cases reported to the Dansih Cholinesterase Research Unit. Acta Anaesth Scand1978; 22: 371–380.
