In a single-blind controlled study, forty children with congenital heart disease were premedicated with oral trimeprazine 3 mg/kg and either intramuscular morphine 0.1 mg/kg or oral ketamine 10 mg/kg. Cardiovascular and respiratory effects of premedication and degree of sedation induced were similar in the two groups of patients. Oral ketamine is a safe and effective premedicant in this group of patients.
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GrantI.S., NimmoW.S., McNicolL.R., ClementsJ.A.Ketamine disposition in children and adults. Br J Anaesth1983; 55: 1107–1111.
