Treatment of Severe Digoxin Toxicity with Digoxin-Specific Antibody Fragments

Katz AM . Effects of digitalis on cell biochemistry: sodium pump inhibition. J Am Coll Cardiol 1985; 5:16A–21A.

Bismuth C , Gaultier M , Conso F , Efthymion ML . Hyperkalemia in acute digitalis poisoning: prognostic significance and therapeutic implications. Clin Toxicol 1973; 6:153–62.

Smith TW , Artman EM , Friedman PL , Blatt CM , Marsh JD . Digitalis glycosides: mechanisms and manifestations of toxicity. Progress in Cardiovascular Diseases 1984; xxvii, i.

Bigger JT , Strauss HC . Digitalis toxicity: drug interactions promoting toxicity and the management of toxicity. Semin Drug Treatment 1972; 2:147–177.

Lalonde RL , Deshparde R , Hamilton PP . Acceleration of digoxin clearance by activated charcoal. Clin Pharmacol Ther 1985; 37:367–371.

Warren SE , Fanestil DD . Digoxin overdose: limitation of haemoperfusion-haemodialysis treatment. JAMA 1979; 242:2100–2101.

Butler VP , Chen JP . Digoxin-specific antibodies. Proc Natl Acad Sci USA 1972; 57:71–78.

Schmidt DH , Butler VP . Immunological protection against digoxin toxicity. J Clin Invest 1971; 50:866–71.

Curd J , Smith TW , Jatson JC , Haber E. The inolation of digoxin-specific antibody and its use in reversing the effects of digoxin. Proc Natl Acad Sci USA 1971; 68:2401–06.

Anderson D , Penny R , O'Rourke MF . Anti-digoxin antibody in digoxin intoxication. Aust NZ J Med 1981; 11:480–483.

Smith TW , Haber E , Yeatman L , Butler VP . Reversal of advanced digoxin intoxication with Fab fragments of digoxin-specific antibodies. N Engl J Med 1976; 294:797–800.

Smith TW , Butler VP , Haber E et al. Treatment of life-threatening digitalis intoxication with digoxin-specific Fab antibody fragments: experience in 26 cases. N Engl J Med 1982; 307:1357–62.

Wegner TL , Butler VP , Haber E , Smith TW . Treatment of 63 severely digitalis toxic patients with digoxin-specific antibody fragments. J Am Coll Cardiol 1985; 5 (Suppl):118A–123A.

Smolarz A , Roesch E , Lenz H , Neubert P , Abshagen U. Report of experiences in the treatment of 16 cases of severe glycoside poisoning with digitalis antibody fragments (Fab). Z Kardiol 1984; 73:113–9.

Spiegel A , Marchlinski FE . Time course for reversal of digoxin toxicity with digoxin-specific antibody fragments. Am Heart J 1985; 109:1397–1399.

Hess T , Stuck P , Barandum S , Scholtysik G , Rienen W. Treatment of a case of lanatoside C intoxication with digoxin specific Fab antibody fragments. Am Heart J 1979; 98:767.