A study was conducted in puppies of one litter beginning before they were three weeks old and repeated up to six times in the first four months of life to determine whether any age-related changes in peak plasma lignocaine levels occurred following tracheal spray. These were significantly higher in the youngest group (less than 20 days) than in dogs 2-3 months of age. There was a significant negative correlation between peak plasma levels and age up to four months. The maximum level attained by any puppy was 4.48 ug/ml after 4 mg/kg tracheal lignocaine spray.
PeltonD.A., DalyM., CooperP.D., ConnA.W.Plasma lignocaine concentrations following topical aerosol application to the trachea and bronchi. Can Anesth Soc J1970; 17: 250.
HastingsC.L., BrownT.C.K., EyresR.L., OppenheimR.C.The influence of age on lignocaine pharmacokinetics during early life in puppies. Anaesth Intens Care (in press).
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PatelR.I., PetersonR.G., AldreteJ.A.Endotracheal compared with intravenous injection of 3 mg/kg of lignocaine. Anaesthesia1981; 36: 772.
