A mixed micelle formulation of diazepam was compared with midazolam and diazepam in propylene glycol for evidence of venous intolerance following IV injection. The overall incidence of venous morbidity was 17% for diazepam mixed micelle, 26% for midazolam and 90% for diazepam in propylene glycol. Diazepam mixed micelle is suggested as a preferable alternative to the standard formulation.
KawarP., DundeeJ.W.Frequency of pain on injection and venous sequelae following the IV administration of certain anaesthetics and sedatives. Br J Anaesth1980; 54: 935–939.
Schou OlesenA., HuttelM.S.Local reactions to IV diazepam in three different formulations. Br J Anaesth1980; 52: 609–612.
4.
MartinD.F., TweedleD.E.F.Venous complications of two diazepam preparations related to size of vein. Br J Anaesth1983; 55: 779–782.
5.
MattilaM.A.K., RuoppiM., KorhonenM., LarniH.M., ValtonenL., HeikkinenH.Prevention of diazepam induced thrombophlebitis with cremophor as a solvent. Br J Anaesth1979; 51: 889–894.
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JensenS., HuttelM.S., Schou OlesenA.Venous complications after IV administration of Diazemuls (diazepam) and Dormicum (midazolam)Br J Anaesth1981; 53: 1083–1086.
